Analysis of the DNA adducts of phenyl glycidyl ether in a calf thymus DNA hydrolysate by capillary zone electrophoresis-electrospray mass spectrometry : evidence for phosphate alkylation

Calf thymus DNA was reacted in vitro with phenyl glycidyl ether (PGE) and was hydrolysed enzymatically, to the 5'-monophosphate nucleotides using deoxyribonuclease I (DNA-ase I) and nuclease P1. The adducts were concentrated using solid phase extraction (SPE), on a polystyrene divinylbenzene co...

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Veröffentlicht in:	Carcinogenesis (New York) 1998-06, Vol.19 (6), p.1077-1086
Hauptverfasser:	DEFORCE, D. L. D, LEMIERE, F, HOES, I, MILLECAMPS, R. E. M, ESMANS, E. L, DE LEENHEER, A, VAN DEN EECKHOUT, E. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cattle Chemical agents DNA - drug effects DNA Adducts - analysis Electrophoresis, Capillary - methods Mass Spectrometry - methods Medical sciences Phenyl Ethers - pharmacology Phosphates - metabolism Spectrophotometry, Ultraviolet Thymus Gland - drug effects Thymus Gland - metabolism Tumors
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