Mutational Analysis of the STAT6 SH2 Domain

The SH2 domain of the STAT family of transcription factors is essential for STAT binding to phosphorylated cytoplasmic domains of activated cytokine receptors. Furthermore, the same domain mediates dimerization of activated STAT monomers, a prerequisite for DNA binding by this family of proteins. To...

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Veröffentlicht in:	The Journal of biological chemistry 1998-07, Vol.273 (28), p.17634-17642
Hauptverfasser:	Mikita, T, Daniel, C, Wu, P, Schindler, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Amino Acid Substitution Cell Line DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Interleukin-4 - metabolism Molecular Sequence Data Mutagenesis Phosphorylation Sequence Homology, Amino Acid src Homology Domains STAT6 Transcription Factor Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - metabolism Tyrosine - metabolism
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