A new biodegradable polythiourethane as controlled release matrix polymer
[Display omitted] The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a...
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| Veröffentlicht in: | International journal of pharmaceutics 2015-03, Vol.480 (1-2), p.63-72 |
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| container_title | International journal of pharmaceutics |
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| creator | Campiñez, M.D. Ferris, C. de Paz, M.V. Aguilar-de-Leyva, A. Galbis, J. Caraballo, I. |
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The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a direct compression process. Furthermore, the ability of this polymer to act as controlled release matrix forming excipient has been studied. Four batches of matrices containing 10–40% of polymer and theophylline anhydrous as model drug have been manufactured. Release studies have been carried out using the paddle method and the polymer percolation threshold has been estimated. The principal parameters of the SeDeM Expert system, such as the parametric profile (mean radius) and the good compression index (IGC=4.59) for the polymer are very close to the values considered as adequate for direct compression even with no addition of flow agents. Furthermore, the results of the drug release studies show a high ability of the polymer to control the drug release. The excipient percolation threshold has been estimated between 20% and 30% w/w of polymer. |
| doi_str_mv | 10.1016/j.ijpharm.2015.01.011 |
| format | Article |
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The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a direct compression process. Furthermore, the ability of this polymer to act as controlled release matrix forming excipient has been studied. Four batches of matrices containing 10–40% of polymer and theophylline anhydrous as model drug have been manufactured. Release studies have been carried out using the paddle method and the polymer percolation threshold has been estimated. The principal parameters of the SeDeM Expert system, such as the parametric profile (mean radius) and the good compression index (IGC=4.59) for the polymer are very close to the values considered as adequate for direct compression even with no addition of flow agents. Furthermore, the results of the drug release studies show a high ability of the polymer to control the drug release. The excipient percolation threshold has been estimated between 20% and 30% w/w of polymer.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2015.01.011</identifier><identifier>PMID: 25579868</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biodegradable polythiourethane ; Chemistry, Pharmaceutical - methods ; Delayed-Action Preparations ; Drug Compounding - methods ; Drug Liberation ; Excipients - chemistry ; Inert matrices ; Percolation theory ; Percolation threshold ; Polymers - chemistry ; Polyurethanes - chemistry ; SeDeM expert system ; Theophylline - administration & dosage ; Theophylline - chemistry</subject><ispartof>International journal of pharmaceutics, 2015-03, Vol.480 (1-2), p.63-72</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-f470c55ed3e1ba007b121068cd6811ca580358bd45287f5335e55d83a4df55f13</citedby><cites>FETCH-LOGICAL-c365t-f470c55ed3e1ba007b121068cd6811ca580358bd45287f5335e55d83a4df55f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517315000137$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25579868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campiñez, M.D.</creatorcontrib><creatorcontrib>Ferris, C.</creatorcontrib><creatorcontrib>de Paz, M.V.</creatorcontrib><creatorcontrib>Aguilar-de-Leyva, A.</creatorcontrib><creatorcontrib>Galbis, J.</creatorcontrib><creatorcontrib>Caraballo, I.</creatorcontrib><title>A new biodegradable polythiourethane as controlled release matrix polymer</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a direct compression process. Furthermore, the ability of this polymer to act as controlled release matrix forming excipient has been studied. Four batches of matrices containing 10–40% of polymer and theophylline anhydrous as model drug have been manufactured. Release studies have been carried out using the paddle method and the polymer percolation threshold has been estimated. The principal parameters of the SeDeM Expert system, such as the parametric profile (mean radius) and the good compression index (IGC=4.59) for the polymer are very close to the values considered as adequate for direct compression even with no addition of flow agents. Furthermore, the results of the drug release studies show a high ability of the polymer to control the drug release. The excipient percolation threshold has been estimated between 20% and 30% w/w of polymer.</description><subject>Biodegradable polythiourethane</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Delayed-Action Preparations</subject><subject>Drug Compounding - methods</subject><subject>Drug Liberation</subject><subject>Excipients - chemistry</subject><subject>Inert matrices</subject><subject>Percolation theory</subject><subject>Percolation threshold</subject><subject>Polymers - chemistry</subject><subject>Polyurethanes - chemistry</subject><subject>SeDeM expert system</subject><subject>Theophylline - administration & dosage</subject><subject>Theophylline - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EgvL4CaAcuaR4465jTghVvKRKXOBsOfaGukrqYidA_z0pLVyRRtrLtzs7w9g58DFwkFeLsV-s5ia244IDjjkMgj02AlWKXExKuc9GXJQqRyjFETtOacE5lwWIQ3ZUIJbXSqoRe7rNlvSZVT44eovGmaqhbBWadTf3oY_Uzc2SMpMyG5ZdDE1DLovUkEmUtaaL_uuHbimesoPaNInOdvOEvd7fvUwf89nzw9P0dpZbIbHL60nJLSI5QVAZzssKCuBSWScVgDWouEBVuQkWqqxRCCREp4SZuBqxBnHCLrd3VzG895Q63fpkqWmGR0OfNMghnOBSigHFLWpjSClSrVfRtyauNXC9aVEv9K5FvWlRcxi0sbjYWfRVS-5v67e2AbjZAjQE_fAUdbKelpacj2Q77YL_x-IbOBWGBQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Campiñez, M.D.</creator><creator>Ferris, C.</creator><creator>de Paz, M.V.</creator><creator>Aguilar-de-Leyva, A.</creator><creator>Galbis, J.</creator><creator>Caraballo, I.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>A new biodegradable polythiourethane as controlled release matrix polymer</title><author>Campiñez, M.D. ; Ferris, C. ; de Paz, M.V. ; Aguilar-de-Leyva, A. ; Galbis, J. ; Caraballo, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-f470c55ed3e1ba007b121068cd6811ca580358bd45287f5335e55d83a4df55f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biodegradable polythiourethane</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Delayed-Action Preparations</topic><topic>Drug Compounding - methods</topic><topic>Drug Liberation</topic><topic>Excipients - chemistry</topic><topic>Inert matrices</topic><topic>Percolation theory</topic><topic>Percolation threshold</topic><topic>Polymers - chemistry</topic><topic>Polyurethanes - chemistry</topic><topic>SeDeM expert system</topic><topic>Theophylline - administration & dosage</topic><topic>Theophylline - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campiñez, M.D.</creatorcontrib><creatorcontrib>Ferris, C.</creatorcontrib><creatorcontrib>de Paz, M.V.</creatorcontrib><creatorcontrib>Aguilar-de-Leyva, A.</creatorcontrib><creatorcontrib>Galbis, J.</creatorcontrib><creatorcontrib>Caraballo, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campiñez, M.D.</au><au>Ferris, C.</au><au>de Paz, M.V.</au><au>Aguilar-de-Leyva, A.</au><au>Galbis, J.</au><au>Caraballo, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new biodegradable polythiourethane as controlled release matrix polymer</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>480</volume><issue>1-2</issue><spage>63</spage><epage>72</epage><pages>63-72</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a direct compression process. Furthermore, the ability of this polymer to act as controlled release matrix forming excipient has been studied. Four batches of matrices containing 10–40% of polymer and theophylline anhydrous as model drug have been manufactured. Release studies have been carried out using the paddle method and the polymer percolation threshold has been estimated. The principal parameters of the SeDeM Expert system, such as the parametric profile (mean radius) and the good compression index (IGC=4.59) for the polymer are very close to the values considered as adequate for direct compression even with no addition of flow agents. Furthermore, the results of the drug release studies show a high ability of the polymer to control the drug release. The excipient percolation threshold has been estimated between 20% and 30% w/w of polymer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25579868</pmid><doi>10.1016/j.ijpharm.2015.01.011</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biodegradable polythiourethane Chemistry, Pharmaceutical - methods Delayed-Action Preparations Drug Compounding - methods Drug Liberation Excipients - chemistry Inert matrices Percolation theory Percolation threshold Polymers - chemistry Polyurethanes - chemistry SeDeM expert system Theophylline - administration & dosage Theophylline - chemistry |
| title | A new biodegradable polythiourethane as controlled release matrix polymer |
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