Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants

[Display omitted] In this study, water-swellable multiblock copolymers composed of semi-crystalline poly(ϵ-caprolactone) [PCL] blocks and amorphous blocks consisting of poly(d,l-lactide) (PDLLA) and poly(ethylene glycol) (PEG) [PDLLA–PEG] were synthesized. The block ratio of these [PDLLA–PEG]-b-[PCL...

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Veröffentlicht in:	International journal of pharmaceutics 2015-03, Vol.480 (1-2), p.73-83
Hauptverfasser:	Stanković, Milica, Hiemstra, Christine, de Waard, Hans, Zuidema, Johan, Steendam, Rob, Frijlink, Henderik W., Hinrichs, Wouter L.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bovine serum albumin Chemistry, Pharmaceutical - methods Crystallization Delayed-Action Preparations Drug Implants Drug Liberation Hot melt extrusion Hydrophobic and Hydrophilic Interactions Lysozyme Muramidase - administration & dosage Muramidase - chemistry Polyesters - chemistry Polyethylene Glycols - chemistry Polymer degradation Polymer implants Proteins - administration & dosage Proteins - chemistry Protein–polymer interaction Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Water - chemistry
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