Treatment of KPC-producing Enterobacteriaceae: suboptimal efficacy of polymyxins

Treatment of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections (KPC-EI) remains a challenge. Combined therapy has been proposed as the best choice, but there are no clear data showing which combination therapy is superior. Our aim was to evaluate the effectiveness of antimi...

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Veröffentlicht in:	Clinical microbiology and infection 2015-02, Vol.21 (2), p.179.e1-179.e7
Hauptverfasser:	de Oliveira, M.S., de Assis, D.B., Freire, M.P., Boas do Prado, G.V., Machado, A.S., Abdala, E., Pierrotti, L.C., Mangini, C., Campos, L., Caiaffa Filho, H.H., Levin, A.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Bacteremia - drug therapy Bacteremia - microbiology Bacteremia - mortality beta-Lactamases - secretion Brazil Carbapenem resistance Child Child, Preschool Cohort Studies Enterobacteriaceae - enzymology Enterobacteriaceae - isolation & purification Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - microbiology Enterobacteriaceae Infections - mortality Female Humans Infant KPC Male Middle Aged mortality Polymyxins - therapeutic use Retrospective Studies Survival Analysis Tertiary Care Centers treatment Treatment Outcome Young Adult
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