Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats
Abstract The study described here investigated the effects of extracorporeal shock wave therapy (ESWT) on functional recovery and neurotrophin-3 expression in the spinal cord after sciatic nerve injury in rats. Forty-five 8-wk-old rats were used and randomly divided into three groups: An experimenta...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2015-03, Vol.41 (3), p.790-796 |
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| description | Abstract The study described here investigated the effects of extracorporeal shock wave therapy (ESWT) on functional recovery and neurotrophin-3 expression in the spinal cord after sciatic nerve injury in rats. Forty-five 8-wk-old rats were used and randomly divided into three groups: An experimental group, a control group and a sham group. The experimental group received ESWT after the nerve-crushing damage. The sciatic functional index and Dartfish Software were used to determine the effect of sciatic nerve damage on functional changes. A 1-cm length of spinal cord encompassing the L4–6 level was removed for Western blot analysis. The sciatic functional index significantly changed in both the ESWT and control groups after impairment. In the time course evaluation of the ankle angle in the toe off, the ESWT group had statistically significant increases from day 21 onward. There was a significant difference in neurotrophin-3 expression between the groups on days 1, 7 and 14 after impairment. Early application of ESWT increased the expression of neurotrophin-3 and neurotrophin-3 mRNA, and daily therapy facilitated the activity of macrophages and Schwann cells, which affect the survival and regeneration of neurons. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2014.10.015 |
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Forty-five 8-wk-old rats were used and randomly divided into three groups: An experimental group, a control group and a sham group. The experimental group received ESWT after the nerve-crushing damage. The sciatic functional index and Dartfish Software were used to determine the effect of sciatic nerve damage on functional changes. A 1-cm length of spinal cord encompassing the L4–6 level was removed for Western blot analysis. The sciatic functional index significantly changed in both the ESWT and control groups after impairment. In the time course evaluation of the ankle angle in the toe off, the ESWT group had statistically significant increases from day 21 onward. There was a significant difference in neurotrophin-3 expression between the groups on days 1, 7 and 14 after impairment. Early application of ESWT increased the expression of neurotrophin-3 and neurotrophin-3 mRNA, and daily therapy facilitated the activity of macrophages and Schwann cells, which affect the survival and regeneration of neurons.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2014.10.015</identifier><identifier>PMID: 25619787</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Blotting, Western ; Disease Models, Animal ; High-Energy Shock Waves ; Male ; Nerve Growth Factors - metabolism ; Peripheral nerves ; Radiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Rehabilitation ; Sciatic Nerve - injuries ; Sciatic nerves ; Sciatic Neuropathy - physiopathology ; Sciatic Neuropathy - therapy ; Shock waves ; Software</subject><ispartof>Ultrasound in medicine & biology, 2015-03, Vol.41 (3), p.790-796</ispartof><rights>World Federation for Ultrasound in Medicine & Biology</rights><rights>2015 World Federation for Ultrasound in Medicine & Biology</rights><rights>Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-8b0eed0a74b1e4299d3b70f25437e01c99dd76e0ff3ca0d96525ff037ccdef3a3</citedby><cites>FETCH-LOGICAL-c571t-8b0eed0a74b1e4299d3b70f25437e01c99dd76e0ff3ca0d96525ff037ccdef3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2014.10.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25619787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jung-Ho</creatorcontrib><creatorcontrib>Kim, Seong-Gil</creatorcontrib><title>Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Abstract The study described here investigated the effects of extracorporeal shock wave therapy (ESWT) on functional recovery and neurotrophin-3 expression in the spinal cord after sciatic nerve injury in rats. Forty-five 8-wk-old rats were used and randomly divided into three groups: An experimental group, a control group and a sham group. The experimental group received ESWT after the nerve-crushing damage. The sciatic functional index and Dartfish Software were used to determine the effect of sciatic nerve damage on functional changes. A 1-cm length of spinal cord encompassing the L4–6 level was removed for Western blot analysis. The sciatic functional index significantly changed in both the ESWT and control groups after impairment. In the time course evaluation of the ankle angle in the toe off, the ESWT group had statistically significant increases from day 21 onward. There was a significant difference in neurotrophin-3 expression between the groups on days 1, 7 and 14 after impairment. Early application of ESWT increased the expression of neurotrophin-3 and neurotrophin-3 mRNA, and daily therapy facilitated the activity of macrophages and Schwann cells, which affect the survival and regeneration of neurons.</description><subject>Animals</subject><subject>Blotting, Western</subject><subject>Disease Models, Animal</subject><subject>High-Energy Shock Waves</subject><subject>Male</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Peripheral nerves</subject><subject>Radiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function</subject><subject>Rehabilitation</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic nerves</subject><subject>Sciatic Neuropathy - physiopathology</subject><subject>Sciatic Neuropathy - therapy</subject><subject>Shock waves</subject><subject>Software</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxi0EokvhFZDFiUu2tvPHGw5IaNnSShVI3SK4WY49VrzNxqmdrNin4VWZaAtCnDhZ8nzfN5r5DSFvOFtyxquL3XLqxqjTHmzjw1IwXmBhyXj5hCz4StaZqPn3p2TBcsazshL1GXmR0o4xJqtcPidnoqx4LVdyQX5unAMzJhoc3fzAVBPiECLojm7bYO7pN30AetdC1MORhp5eTr0ZfehRcAsmHCAeqe4t_QxTDGMMQ-v7LMesIUJKKKS-p2MLdDv42bQO0VLtRoh0HafUgqVb4_XoDUZE7HXd7ybMRNetHtNL8szpLsGrx_ecfL3c3K2vspsvn67XH24yU0o-ZquGAVimZdFwKERd27yRzImyyCUwbvDDygqYc7nRzNZVKUrnWC6NseBynZ-Tt6fcIYaHCdKo9j4Z6DrdQ5iS4lVZSlHmUqD03UlqYkgpglND9Hsdj4ozNQNSO_U3IDUDmmsICM2vH_tMDZb_WH8TQcHHkwBw2oOHqJLx0BuwPiIoZYP_vz7v_4kxne-90d09HCHtwhSRBs6lklBMbedTmS-FF3gkDNf2C5PwwQQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Lee, Jung-Ho</creator><creator>Kim, Seong-Gil</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats</title><author>Lee, Jung-Ho ; Kim, Seong-Gil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-8b0eed0a74b1e4299d3b70f25437e01c99dd76e0ff3ca0d96525ff037ccdef3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Blotting, Western</topic><topic>Disease Models, Animal</topic><topic>High-Energy Shock Waves</topic><topic>Male</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Peripheral nerves</topic><topic>Radiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery of Function</topic><topic>Rehabilitation</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic nerves</topic><topic>Sciatic Neuropathy - physiopathology</topic><topic>Sciatic Neuropathy - therapy</topic><topic>Shock waves</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jung-Ho</creatorcontrib><creatorcontrib>Kim, Seong-Gil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jung-Ho</au><au>Kim, Seong-Gil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>41</volume><issue>3</issue><spage>790</spage><epage>796</epage><pages>790-796</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>Abstract The study described here investigated the effects of extracorporeal shock wave therapy (ESWT) on functional recovery and neurotrophin-3 expression in the spinal cord after sciatic nerve injury in rats. Forty-five 8-wk-old rats were used and randomly divided into three groups: An experimental group, a control group and a sham group. The experimental group received ESWT after the nerve-crushing damage. The sciatic functional index and Dartfish Software were used to determine the effect of sciatic nerve damage on functional changes. A 1-cm length of spinal cord encompassing the L4–6 level was removed for Western blot analysis. The sciatic functional index significantly changed in both the ESWT and control groups after impairment. In the time course evaluation of the ankle angle in the toe off, the ESWT group had statistically significant increases from day 21 onward. There was a significant difference in neurotrophin-3 expression between the groups on days 1, 7 and 14 after impairment. 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| subjects | Animals Blotting, Western Disease Models, Animal High-Energy Shock Waves Male Nerve Growth Factors - metabolism Peripheral nerves Radiology Random Allocation Rats Rats, Sprague-Dawley Recovery of Function Rehabilitation Sciatic Nerve - injuries Sciatic nerves Sciatic Neuropathy - physiopathology Sciatic Neuropathy - therapy Shock waves Software |
| title | Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats |
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