Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement
Objective To investigate the changes of increased F-18 fluorodeoxyglucose ( 18 F-FDG) uptake around the prosthesis and its ability to differentiate local recurrence from postsurgical change after endoprosthetic replacement in extremity osteosarcoma. Materials and methods A total of 355 positron emis...
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| Veröffentlicht in: | Skeletal radiology 2015-04, Vol.44 (4), p.529-537 |
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| creator | Chang, Kyoung Jin Kong, Chang-Bae Cho, Wan Hyeong Jeon, Dae-Geun Lee, Soo-Yong Lim, Ilhan Lim, Sang Moo |
| description | Objective
To investigate the changes of increased F-18 fluorodeoxyglucose (
18
F-FDG) uptake around the prosthesis and its ability to differentiate local recurrence from postsurgical change after endoprosthetic replacement in extremity osteosarcoma.
Materials and methods
A total of 355 positron emission tomography (PET)/computed tomography (CT) scans in 109 extremity osteosarcoma patients were retrospectively analyzed. All patients were followed up with
18
F-FDG PET/CT for more than 3 years after tumor resection. For semiquantitative assessment, we drew a volume of interest around the entire prosthesis of the extremity and measured the maximum standardized uptake value (SUVmax). Independent samples
t
test was used to compare SUVmax at each follow-up time. SUVmax at 3 months (SUV1) and SUVmax at the time of local recurrence in patients with recurrence or at the last follow-up in others (SUV2) were compared using the Mann–Whitney test. Diagnostic performances of PET parameters were assessed using ROC curve analyses.
Results
Nine patients (8 %) showed a local recurrence. Mean SUVmax at 3, 12, 24, and 36 months was 3.1 ± 1.5, 3.8 ± 1.9, 3.6 ± 1.9, and 3.7 ± 1.5 respectively. In ROC curve analysis, the combination of SUV2 >4.6 and ΔSUV >75.0 was a more useful parameter for predicting local recurrence than SUV2 or ΔSUV alone. The sensitivity, specificity, and accuracy for identifying local recurrence were 89, 76, 77 % for SUV2; 78, 81, 81 % for ΔSUV; and 78, 94, 93 % for the combined criterion respectively.
Conclusion
The combination of SUV2 and ΔSUV was more useful than the SUV2 or ΔSUV used alone for the prediction of local recurrence. |
| doi_str_mv | 10.1007/s00256-014-2063-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1655723705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1655723705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1897-86ec922d0407949d9c69e8731b224bd1dff816db757349d911d2cba2ba85b0453</originalsourceid><addsrcrecordid>eNp9kcFu1TAQRS0Eoq-FD2CDvGQT8NiJnSxR6StIldjQteXYk9eUxA62I9p_4iNxSGHJaqS59x7N6BLyBth7YEx9SIzxRlYM6oozKSr1jBygFrziIOE5OTAhiyLq9oycp3TPGCjVyJfkjDe1ANaJA_l1m3BYJ48p0TDQ0duIJqGj0B6r46drui7ZfEc6hEgdZrR59Cc6BWsmGtGuMaK3WHJ0MXlEnxP9OeY7ig854jzmRxpSxpBMtGE2tCxNLvQ_nrTG07iD0gYOnhrvKHoXllhid5hHW8RlMhbnwn5FXgxmSvj6aV6Q2-PVt8vP1c3X6y-XH28qC22nqlai7Th3rGaqqzvXWdlhqwT0nNe9AzcMLUjXq0aJTQZw3PaG96ZtelY34oK827nljB8rpqznMVmcJuMxrEmDbBrFhWKbFXarLReniINe4jib-KiB6a0kvZekS0l6K0mrknn7hF_7Gd2_xN9WioHvhlQkf8Ko78MafXn5P9TfdzqgmA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1655723705</pqid></control><display><type>article</type><title>Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chang, Kyoung Jin ; Kong, Chang-Bae ; Cho, Wan Hyeong ; Jeon, Dae-Geun ; Lee, Soo-Yong ; Lim, Ilhan ; Lim, Sang Moo</creator><creatorcontrib>Chang, Kyoung Jin ; Kong, Chang-Bae ; Cho, Wan Hyeong ; Jeon, Dae-Geun ; Lee, Soo-Yong ; Lim, Ilhan ; Lim, Sang Moo</creatorcontrib><description>Objective
To investigate the changes of increased F-18 fluorodeoxyglucose (
18
F-FDG) uptake around the prosthesis and its ability to differentiate local recurrence from postsurgical change after endoprosthetic replacement in extremity osteosarcoma.
Materials and methods
A total of 355 positron emission tomography (PET)/computed tomography (CT) scans in 109 extremity osteosarcoma patients were retrospectively analyzed. All patients were followed up with
18
F-FDG PET/CT for more than 3 years after tumor resection. For semiquantitative assessment, we drew a volume of interest around the entire prosthesis of the extremity and measured the maximum standardized uptake value (SUVmax). Independent samples
t
test was used to compare SUVmax at each follow-up time. SUVmax at 3 months (SUV1) and SUVmax at the time of local recurrence in patients with recurrence or at the last follow-up in others (SUV2) were compared using the Mann–Whitney test. Diagnostic performances of PET parameters were assessed using ROC curve analyses.
Results
Nine patients (8 %) showed a local recurrence. Mean SUVmax at 3, 12, 24, and 36 months was 3.1 ± 1.5, 3.8 ± 1.9, 3.6 ± 1.9, and 3.7 ± 1.5 respectively. In ROC curve analysis, the combination of SUV2 >4.6 and ΔSUV >75.0 was a more useful parameter for predicting local recurrence than SUV2 or ΔSUV alone. The sensitivity, specificity, and accuracy for identifying local recurrence were 89, 76, 77 % for SUV2; 78, 81, 81 % for ΔSUV; and 78, 94, 93 % for the combined criterion respectively.
Conclusion
The combination of SUV2 and ΔSUV was more useful than the SUV2 or ΔSUV used alone for the prediction of local recurrence.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-014-2063-7</identifier><identifier>PMID: 25431093</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Bone Neoplasms - diagnosis ; Bone Neoplasms - surgery ; Extremities - diagnostic imaging ; Extremities - surgery ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Follow-Up Studies ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Multimodal Imaging - methods ; Neoplasm Recurrence, Local - diagnosis ; Nuclear Medicine ; Orthopedics ; Osteosarcoma - diagnosis ; Osteosarcoma - surgery ; Pathology ; Positron-Emission Tomography ; Prostheses and Implants ; Prosthesis Implantation ; Radiology ; Radiopharmaceuticals - pharmacokinetics ; Reproducibility of Results ; Retrospective Studies ; ROC Curve ; Scientific Article ; Sensitivity and Specificity ; Tomography, X-Ray Computed</subject><ispartof>Skeletal radiology, 2015-04, Vol.44 (4), p.529-537</ispartof><rights>ISS 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1897-86ec922d0407949d9c69e8731b224bd1dff816db757349d911d2cba2ba85b0453</citedby><cites>FETCH-LOGICAL-c1897-86ec922d0407949d9c69e8731b224bd1dff816db757349d911d2cba2ba85b0453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-014-2063-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-014-2063-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25431093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Kyoung Jin</creatorcontrib><creatorcontrib>Kong, Chang-Bae</creatorcontrib><creatorcontrib>Cho, Wan Hyeong</creatorcontrib><creatorcontrib>Jeon, Dae-Geun</creatorcontrib><creatorcontrib>Lee, Soo-Yong</creatorcontrib><creatorcontrib>Lim, Ilhan</creatorcontrib><creatorcontrib>Lim, Sang Moo</creatorcontrib><title>Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objective
To investigate the changes of increased F-18 fluorodeoxyglucose (
18
F-FDG) uptake around the prosthesis and its ability to differentiate local recurrence from postsurgical change after endoprosthetic replacement in extremity osteosarcoma.
Materials and methods
A total of 355 positron emission tomography (PET)/computed tomography (CT) scans in 109 extremity osteosarcoma patients were retrospectively analyzed. All patients were followed up with
18
F-FDG PET/CT for more than 3 years after tumor resection. For semiquantitative assessment, we drew a volume of interest around the entire prosthesis of the extremity and measured the maximum standardized uptake value (SUVmax). Independent samples
t
test was used to compare SUVmax at each follow-up time. SUVmax at 3 months (SUV1) and SUVmax at the time of local recurrence in patients with recurrence or at the last follow-up in others (SUV2) were compared using the Mann–Whitney test. Diagnostic performances of PET parameters were assessed using ROC curve analyses.
Results
Nine patients (8 %) showed a local recurrence. Mean SUVmax at 3, 12, 24, and 36 months was 3.1 ± 1.5, 3.8 ± 1.9, 3.6 ± 1.9, and 3.7 ± 1.5 respectively. In ROC curve analysis, the combination of SUV2 >4.6 and ΔSUV >75.0 was a more useful parameter for predicting local recurrence than SUV2 or ΔSUV alone. The sensitivity, specificity, and accuracy for identifying local recurrence were 89, 76, 77 % for SUV2; 78, 81, 81 % for ΔSUV; and 78, 94, 93 % for the combined criterion respectively.
Conclusion
The combination of SUV2 and ΔSUV was more useful than the SUV2 or ΔSUV used alone for the prediction of local recurrence.</description><subject>Adolescent</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - surgery</subject><subject>Extremities - diagnostic imaging</subject><subject>Extremities - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multimodal Imaging - methods</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Osteosarcoma - diagnosis</subject><subject>Osteosarcoma - surgery</subject><subject>Pathology</subject><subject>Positron-Emission Tomography</subject><subject>Prostheses and Implants</subject><subject>Prosthesis Implantation</subject><subject>Radiology</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Scientific Article</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1TAQRS0Eoq-FD2CDvGQT8NiJnSxR6StIldjQteXYk9eUxA62I9p_4iNxSGHJaqS59x7N6BLyBth7YEx9SIzxRlYM6oozKSr1jBygFrziIOE5OTAhiyLq9oycp3TPGCjVyJfkjDe1ANaJA_l1m3BYJ48p0TDQ0duIJqGj0B6r46drui7ZfEc6hEgdZrR59Cc6BWsmGtGuMaK3WHJ0MXlEnxP9OeY7ig854jzmRxpSxpBMtGE2tCxNLvQ_nrTG07iD0gYOnhrvKHoXllhid5hHW8RlMhbnwn5FXgxmSvj6aV6Q2-PVt8vP1c3X6y-XH28qC22nqlai7Th3rGaqqzvXWdlhqwT0nNe9AzcMLUjXq0aJTQZw3PaG96ZtelY34oK827nljB8rpqznMVmcJuMxrEmDbBrFhWKbFXarLReniINe4jib-KiB6a0kvZekS0l6K0mrknn7hF_7Gd2_xN9WioHvhlQkf8Ko78MafXn5P9TfdzqgmA</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Chang, Kyoung Jin</creator><creator>Kong, Chang-Bae</creator><creator>Cho, Wan Hyeong</creator><creator>Jeon, Dae-Geun</creator><creator>Lee, Soo-Yong</creator><creator>Lim, Ilhan</creator><creator>Lim, Sang Moo</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement</title><author>Chang, Kyoung Jin ; Kong, Chang-Bae ; Cho, Wan Hyeong ; Jeon, Dae-Geun ; Lee, Soo-Yong ; Lim, Ilhan ; Lim, Sang Moo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1897-86ec922d0407949d9c69e8731b224bd1dff816db757349d911d2cba2ba85b0453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Bone Neoplasms - surgery</topic><topic>Extremities - diagnostic imaging</topic><topic>Extremities - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multimodal Imaging - methods</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Osteosarcoma - diagnosis</topic><topic>Osteosarcoma - surgery</topic><topic>Pathology</topic><topic>Positron-Emission Tomography</topic><topic>Prostheses and Implants</topic><topic>Prosthesis Implantation</topic><topic>Radiology</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Scientific Article</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Kyoung Jin</creatorcontrib><creatorcontrib>Kong, Chang-Bae</creatorcontrib><creatorcontrib>Cho, Wan Hyeong</creatorcontrib><creatorcontrib>Jeon, Dae-Geun</creatorcontrib><creatorcontrib>Lee, Soo-Yong</creatorcontrib><creatorcontrib>Lim, Ilhan</creatorcontrib><creatorcontrib>Lim, Sang Moo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Kyoung Jin</au><au>Kong, Chang-Bae</au><au>Cho, Wan Hyeong</au><au>Jeon, Dae-Geun</au><au>Lee, Soo-Yong</au><au>Lim, Ilhan</au><au>Lim, Sang Moo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>44</volume><issue>4</issue><spage>529</spage><epage>537</epage><pages>529-537</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Objective
To investigate the changes of increased F-18 fluorodeoxyglucose (
18
F-FDG) uptake around the prosthesis and its ability to differentiate local recurrence from postsurgical change after endoprosthetic replacement in extremity osteosarcoma.
Materials and methods
A total of 355 positron emission tomography (PET)/computed tomography (CT) scans in 109 extremity osteosarcoma patients were retrospectively analyzed. All patients were followed up with
18
F-FDG PET/CT for more than 3 years after tumor resection. For semiquantitative assessment, we drew a volume of interest around the entire prosthesis of the extremity and measured the maximum standardized uptake value (SUVmax). Independent samples
t
test was used to compare SUVmax at each follow-up time. SUVmax at 3 months (SUV1) and SUVmax at the time of local recurrence in patients with recurrence or at the last follow-up in others (SUV2) were compared using the Mann–Whitney test. Diagnostic performances of PET parameters were assessed using ROC curve analyses.
Results
Nine patients (8 %) showed a local recurrence. Mean SUVmax at 3, 12, 24, and 36 months was 3.1 ± 1.5, 3.8 ± 1.9, 3.6 ± 1.9, and 3.7 ± 1.5 respectively. In ROC curve analysis, the combination of SUV2 >4.6 and ΔSUV >75.0 was a more useful parameter for predicting local recurrence than SUV2 or ΔSUV alone. The sensitivity, specificity, and accuracy for identifying local recurrence were 89, 76, 77 % for SUV2; 78, 81, 81 % for ΔSUV; and 78, 94, 93 % for the combined criterion respectively.
Conclusion
The combination of SUV2 and ΔSUV was more useful than the SUV2 or ΔSUV used alone for the prediction of local recurrence.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25431093</pmid><doi>10.1007/s00256-014-2063-7</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Bone Neoplasms - diagnosis Bone Neoplasms - surgery Extremities - diagnostic imaging Extremities - surgery Female Fluorodeoxyglucose F18 - pharmacokinetics Follow-Up Studies Humans Imaging Male Medicine Medicine & Public Health Multimodal Imaging - methods Neoplasm Recurrence, Local - diagnosis Nuclear Medicine Orthopedics Osteosarcoma - diagnosis Osteosarcoma - surgery Pathology Positron-Emission Tomography Prostheses and Implants Prosthesis Implantation Radiology Radiopharmaceuticals - pharmacokinetics Reproducibility of Results Retrospective Studies ROC Curve Scientific Article Sensitivity and Specificity Tomography, X-Ray Computed |
| title | Usefulness of increased 18F-FDG uptake for detecting local recurrence in patients with extremity osteosarcoma treated with surgical resection and endoprosthetic replacement |
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