Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo
This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agen...
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| Veröffentlicht in: | Nanoscale 2015-02, Vol.7 (8), p.3614-3626 |
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| container_title | Nanoscale |
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| creator | Liu, Junjie Zhang, Beilu Luo, Zhong Ding, Xingwei Li, Jinghua Dai, Liangliang Zhou, Jun Zhao, Xiaojing Ye, Jingya Cai, Kaiyong |
| description | This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agent, via an intermediate linker of a functional polypeptide, which was composed of two functional units: the polycation cell penetrating peptide (CPP) polyarginine, and matrix metalloproteinase 2 (MMP-2) substrate peptide. A series of characterizations confirmed that the system had been successfully constructed. In vitro tests proved that the anticancer drug loading system could efficiently induce cell apoptosis in vitro. More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects. |
| doi_str_mv | 10.1039/c5nr00072f |
| format | Article |
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It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agent, via an intermediate linker of a functional polypeptide, which was composed of two functional units: the polycation cell penetrating peptide (CPP) polyarginine, and matrix metalloproteinase 2 (MMP-2) substrate peptide. A series of characterizations confirmed that the system had been successfully constructed. In vitro tests proved that the anticancer drug loading system could efficiently induce cell apoptosis in vitro. More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects.</description><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c5nr00072f</identifier><identifier>PMID: 25633047</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Apoptosis ; Boronic Acids - chemistry ; Cell Line, Tumor ; Drug Carriers - chemistry ; Drug Screening Assays, Antitumor ; Enzyme-Linked Immunosorbent Assay ; Enzymes - chemistry ; Female ; Hep G2 Cells ; Humans ; Matrix Metalloproteinase 2 - chemistry ; Mice ; Mice, Nude ; Nanomedicine - methods ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Peptides - chemistry ; Phagocytosis ; Serum Albumin - chemistry ; Silicon Dioxide - chemistry</subject><ispartof>Nanoscale, 2015-02, Vol.7 (8), p.3614-3626</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25633047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Junjie</creatorcontrib><creatorcontrib>Zhang, Beilu</creatorcontrib><creatorcontrib>Luo, Zhong</creatorcontrib><creatorcontrib>Ding, Xingwei</creatorcontrib><creatorcontrib>Li, Jinghua</creatorcontrib><creatorcontrib>Dai, Liangliang</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Zhao, Xiaojing</creatorcontrib><creatorcontrib>Ye, Jingya</creatorcontrib><creatorcontrib>Cai, Kaiyong</creatorcontrib><title>Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. 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More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Apoptosis</subject><subject>Boronic Acids - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Enzymes - chemistry</subject><subject>Female</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Matrix Metalloproteinase 2 - chemistry</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Nanomedicine - methods</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Peptides - chemistry</subject><subject>Phagocytosis</subject><subject>Serum Albumin - chemistry</subject><subject>Silicon Dioxide - chemistry</subject><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEYhIMgtlYv_gDJ0ctqPvfjKKV-QMGD3pd3k3c1spusSbZQf70V62l4YBhmhpArzm45k82d0T4yxirRn5ClYIoVUlZiQc5T-mSsbGQpz8hC6FJKpqolgY3_3o9II6Yp-OR2SEdMYQoxzIkmNzgD1IMPE8TszICJ9iHSDPEdM1qa5_EXPzDCtKfO053LMVDw9g924YKc9jAkvDzqirw-bN7WT8X25fF5fb8tJq54LjqosOuVFb3h5lBZadPVgLJXWtcVUwqsqWuhytJyxrntrQDZdA2TpoNarsjNX-oUw9eMKbejSwaHATwelrS81FoLoaU6WK-P1rkb0bZTdCPEfft_ivwBzbxjmg</recordid><startdate>20150228</startdate><enddate>20150228</enddate><creator>Liu, Junjie</creator><creator>Zhang, Beilu</creator><creator>Luo, Zhong</creator><creator>Ding, Xingwei</creator><creator>Li, Jinghua</creator><creator>Dai, Liangliang</creator><creator>Zhou, Jun</creator><creator>Zhao, Xiaojing</creator><creator>Ye, Jingya</creator><creator>Cai, Kaiyong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20150228</creationdate><title>Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo</title><author>Liu, Junjie ; Zhang, Beilu ; Luo, Zhong ; Ding, Xingwei ; Li, Jinghua ; Dai, Liangliang ; Zhou, Jun ; Zhao, Xiaojing ; Ye, Jingya ; Cai, Kaiyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-ba7ebf4d2fc1c37245cb8ae3f45587044adc882466d1011dfd2a39b903cba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Apoptosis</topic><topic>Boronic Acids - chemistry</topic><topic>Cell Line, Tumor</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Enzymes - chemistry</topic><topic>Female</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Matrix Metalloproteinase 2 - chemistry</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Nanomedicine - methods</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Peptides - chemistry</topic><topic>Phagocytosis</topic><topic>Serum Albumin - chemistry</topic><topic>Silicon Dioxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Junjie</creatorcontrib><creatorcontrib>Zhang, Beilu</creatorcontrib><creatorcontrib>Luo, Zhong</creatorcontrib><creatorcontrib>Ding, Xingwei</creatorcontrib><creatorcontrib>Li, Jinghua</creatorcontrib><creatorcontrib>Dai, Liangliang</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Zhao, Xiaojing</creatorcontrib><creatorcontrib>Ye, Jingya</creatorcontrib><creatorcontrib>Cai, Kaiyong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Junjie</au><au>Zhang, Beilu</au><au>Luo, Zhong</au><au>Ding, Xingwei</au><au>Li, Jinghua</au><au>Dai, Liangliang</au><au>Zhou, Jun</au><au>Zhao, Xiaojing</au><au>Ye, Jingya</au><au>Cai, Kaiyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2015-02-28</date><risdate>2015</risdate><volume>7</volume><issue>8</issue><spage>3614</spage><epage>3626</epage><pages>3614-3626</pages><eissn>2040-3372</eissn><abstract>This study reports a biocompatible controlled drug release system based on mesoporous silica nanoparticles (MSNs) for tumor microenvironment responsive drug delivery. It was fabricated by grafting phenylboronic acid conjugated human serum albumin (PBA-HSA) onto the surfaces of MSNs as a sealing agent, via an intermediate linker of a functional polypeptide, which was composed of two functional units: the polycation cell penetrating peptide (CPP) polyarginine, and matrix metalloproteinase 2 (MMP-2) substrate peptide. A series of characterizations confirmed that the system had been successfully constructed. In vitro tests proved that the anticancer drug loading system could efficiently induce cell apoptosis in vitro. More importantly, the in vivo tumor experiments confirmed that the anticancer loading system could efficiently inhibit tumor growth with minimal side effects.</abstract><cop>England</cop><pmid>25633047</pmid><doi>10.1039/c5nr00072f</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Apoptosis Boronic Acids - chemistry Cell Line, Tumor Drug Carriers - chemistry Drug Screening Assays, Antitumor Enzyme-Linked Immunosorbent Assay Enzymes - chemistry Female Hep G2 Cells Humans Matrix Metalloproteinase 2 - chemistry Mice Mice, Nude Nanomedicine - methods Nanoparticles - chemistry Neoplasms - drug therapy Peptides - chemistry Phagocytosis Serum Albumin - chemistry Silicon Dioxide - chemistry |
| title | Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo |
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