Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection

Summary Background To define HBsAg-mutations correlated with different serum HBV-DNA levels in HBV chronically-infected drug-naive patients. Methods This study included 187 patients stratified into the following ranges of serum HBV-DNA:12–2000 IU/ml, 2000–100,000 IU/ml, and >100,000 IU/ml. HBsAg-...

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Veröffentlicht in:	The Journal of infection 2015-03, Vol.70 (3), p.288-298
Hauptverfasser:	Mirabelli, Carmen, Surdo, Matteo, Van Hemert, Formijn, Lian, Zhichao, Salpini, Romina, Cento, Valeria, Cortese, Maria Francesca, Aragri, Marianna, Pollicita, Michela, Alteri, Claudia, Bertoli, Ada, Berkhout, Ben, Micheli, Valeria, Gubertini, Guido, Santoro, Maria Mercedes, Romano, Sara, Visca, Michela, Bernassola, Martina, Longo, Roberta, De Sanctis, Giuseppe Maria, Trimoulet, Pascal, Fleury, Hervè, Marino, Nicoletta, Mazzotta, Francesco, Cappiello, Giuseppina, Spanò, Alberto, Sarrecchia, Cesare, Zhang, Jing Maria, Andreoni, Massimo, Angelico, Mario, Verheyen, Jens, Perno, Carlo Federico, Svicher, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bayes Theorem Carrier State - virology DNA, Viral - blood Female Genotype HBsAg HBV Hepatitis B Surface Antigens - blood Hepatitis B Surface Antigens - chemistry Hepatitis B Surface Antigens - genetics Hepatitis B virus - genetics Hepatitis B, Chronic - virology Humans Infectious Disease Male Middle Aged Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Mutation Serum HBV-DNA Transaminases - blood Virion maturation
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