Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors
Background The aim of this study was to elucidate immunocytochemically whether thyroid specific peroxidase (TPO) and Ki‐67 can complement fine‐needle aspiration (FNA) cytology as useful markers in order to distinguish between follicular adenoma (FA) and follicular carcinoma (FC). Methods We studied...
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| Veröffentlicht in: | Diagnostic cytopathology 2015-03, Vol.43 (3), p.202-209 |
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| creator | Maruta, Junko Hashimoto, Hironobu Yamashita, Hiroto Noguchi, Hitoshi Noguchi, Shiro Kobayashi, Tadao K. Tsuneoka, Hidehiro Takahashi, Mutsuo |
| description | Background
The aim of this study was to elucidate immunocytochemically whether thyroid specific peroxidase (TPO) and Ki‐67 can complement fine‐needle aspiration (FNA) cytology as useful markers in order to distinguish between follicular adenoma (FA) and follicular carcinoma (FC).
Methods
We studied 40 FAs and 68 FCs obtained by surgical resection. FNA cytology smears were divided into two groups: Cytology‐A (Cy‐A) (94 cases) with typical benign cytology and Cytology‐B (Cy‐B) (14 cases) with atypical cytology. FCs were divided into two groups: FC‐I (42 cases) without any poorly differentiated structures and FC‐II (26 cases) with some poorly differentiated structures. Cytology smears and histology from FAs and FCs were studied immunocytochemically for thyroid specific peroxidase (TPO) and Ki‐67.
Results
TPO expression was negative in 12.5% FAs, 21.4% FC‐I, and 46.2% FC‐II. In 68 FC cases, Cy‐B were more frequently observed in TPO‐negative cases (38.1%) than in TPO‐positive cases (12.8%). The mean Ki‐67 LI was 0.46 in FAs, 0.53 in FC‐I, and 1.13 in FC‐II. The high Ki‐67 LI was correlated with Cy‐B. Moreover, higher Ki‐67 LI showed a close relationship with distant metastasis. In 94 Cy‐A cases, 54 cases were FCs. When 38 cases with negative TPO or Ki‐67 LI over 0.62 were extracted from them, as many as 28 cases were FCs, the rate of FCs were significantly higher than the rest.
Conclusion
Therefore, addition of TPO stain and Ki‐67 stain to routine Papanicolaou stain could improve the diagnostic reliability of FNA cytology for FC with high degree of malignancy. Diagn. Cytopathol. 2015;43:202–209. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/dc.23204 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1655520436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1655520436</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4154-75aa421b79c59ee66d497724445dfef8c7b0bef9941fd87ed85acfed5e6c46483</originalsourceid><addsrcrecordid>eNpd0UuLFDEQAOAgijuugr9AAl689Jp03kcZdX0sK4KPY8gkFc2a6bRJt27_e3sfjuCpoOqroqhC6DElJ5SQ_nnwJz3rCb-DNpQY1RHGzF200UqIjhJmjtCD1i4IIaan8j466gU1Qii6QfmLyzPgEvH0faklBdxG8Ckmj0eo5TIF1wC7IeD3qZMKt8mloeE04LFCWYmb0i_AfplKLt8WHEs9TIol5-Tn7NbUvC-1PUT3ossNHt3GY_T59atP2zfd2YfTt9sXZ13iVPBOCed4T3fKeGEApAzcKNVzzkWIELVXO7KDaAynMWgFQQvnIwQB0nPJNTtGz27mjrX8nKFNdp-ah5zdAGVulkohxHouJlf69D96UeY6rNtdKa611Eas6smtmnd7CHasae_qYv_ecQXdDfidMiyHOiX26j82eHv9H_tyex3_-dQmuDx4V39YqZgS9uv56dryTjKtPtpz9gd7xZDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654886895</pqid></control><display><type>article</type><title>Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Maruta, Junko ; Hashimoto, Hironobu ; Yamashita, Hiroto ; Noguchi, Hitoshi ; Noguchi, Shiro ; Kobayashi, Tadao K. ; Tsuneoka, Hidehiro ; Takahashi, Mutsuo</creator><creatorcontrib>Maruta, Junko ; Hashimoto, Hironobu ; Yamashita, Hiroto ; Noguchi, Hitoshi ; Noguchi, Shiro ; Kobayashi, Tadao K. ; Tsuneoka, Hidehiro ; Takahashi, Mutsuo</creatorcontrib><description>Background
The aim of this study was to elucidate immunocytochemically whether thyroid specific peroxidase (TPO) and Ki‐67 can complement fine‐needle aspiration (FNA) cytology as useful markers in order to distinguish between follicular adenoma (FA) and follicular carcinoma (FC).
Methods
We studied 40 FAs and 68 FCs obtained by surgical resection. FNA cytology smears were divided into two groups: Cytology‐A (Cy‐A) (94 cases) with typical benign cytology and Cytology‐B (Cy‐B) (14 cases) with atypical cytology. FCs were divided into two groups: FC‐I (42 cases) without any poorly differentiated structures and FC‐II (26 cases) with some poorly differentiated structures. Cytology smears and histology from FAs and FCs were studied immunocytochemically for thyroid specific peroxidase (TPO) and Ki‐67.
Results
TPO expression was negative in 12.5% FAs, 21.4% FC‐I, and 46.2% FC‐II. In 68 FC cases, Cy‐B were more frequently observed in TPO‐negative cases (38.1%) than in TPO‐positive cases (12.8%). The mean Ki‐67 LI was 0.46 in FAs, 0.53 in FC‐I, and 1.13 in FC‐II. The high Ki‐67 LI was correlated with Cy‐B. Moreover, higher Ki‐67 LI showed a close relationship with distant metastasis. In 94 Cy‐A cases, 54 cases were FCs. When 38 cases with negative TPO or Ki‐67 LI over 0.62 were extracted from them, as many as 28 cases were FCs, the rate of FCs were significantly higher than the rest.
Conclusion
Therefore, addition of TPO stain and Ki‐67 stain to routine Papanicolaou stain could improve the diagnostic reliability of FNA cytology for FC with high degree of malignancy. Diagn. Cytopathol. 2015;43:202–209. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.23204</identifier><identifier>PMID: 25195571</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma, Follicular - metabolism ; Adenocarcinoma, Follicular - pathology ; Adult ; Autoantigens - genetics ; Autoantigens - metabolism ; Female ; follicular tumor ; Humans ; immuocytochemistry ; Iodide Peroxidase - genetics ; Iodide Peroxidase - metabolism ; Iron-Binding Proteins - genetics ; Iron-Binding Proteins - metabolism ; Ki-67 ; Ki-67 Antigen - genetics ; Ki-67 Antigen - metabolism ; Male ; Middle Aged ; Preoperative Period ; thyroid ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; thyroid specific peroxidase</subject><ispartof>Diagnostic cytopathology, 2015-03, Vol.43 (3), p.202-209</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.23204$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.23204$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25195571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruta, Junko</creatorcontrib><creatorcontrib>Hashimoto, Hironobu</creatorcontrib><creatorcontrib>Yamashita, Hiroto</creatorcontrib><creatorcontrib>Noguchi, Hitoshi</creatorcontrib><creatorcontrib>Noguchi, Shiro</creatorcontrib><creatorcontrib>Kobayashi, Tadao K.</creatorcontrib><creatorcontrib>Tsuneoka, Hidehiro</creatorcontrib><creatorcontrib>Takahashi, Mutsuo</creatorcontrib><title>Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>Background
The aim of this study was to elucidate immunocytochemically whether thyroid specific peroxidase (TPO) and Ki‐67 can complement fine‐needle aspiration (FNA) cytology as useful markers in order to distinguish between follicular adenoma (FA) and follicular carcinoma (FC).
Methods
We studied 40 FAs and 68 FCs obtained by surgical resection. FNA cytology smears were divided into two groups: Cytology‐A (Cy‐A) (94 cases) with typical benign cytology and Cytology‐B (Cy‐B) (14 cases) with atypical cytology. FCs were divided into two groups: FC‐I (42 cases) without any poorly differentiated structures and FC‐II (26 cases) with some poorly differentiated structures. Cytology smears and histology from FAs and FCs were studied immunocytochemically for thyroid specific peroxidase (TPO) and Ki‐67.
Results
TPO expression was negative in 12.5% FAs, 21.4% FC‐I, and 46.2% FC‐II. In 68 FC cases, Cy‐B were more frequently observed in TPO‐negative cases (38.1%) than in TPO‐positive cases (12.8%). The mean Ki‐67 LI was 0.46 in FAs, 0.53 in FC‐I, and 1.13 in FC‐II. The high Ki‐67 LI was correlated with Cy‐B. Moreover, higher Ki‐67 LI showed a close relationship with distant metastasis. In 94 Cy‐A cases, 54 cases were FCs. When 38 cases with negative TPO or Ki‐67 LI over 0.62 were extracted from them, as many as 28 cases were FCs, the rate of FCs were significantly higher than the rest.
Conclusion
Therefore, addition of TPO stain and Ki‐67 stain to routine Papanicolaou stain could improve the diagnostic reliability of FNA cytology for FC with high degree of malignancy. Diagn. Cytopathol. 2015;43:202–209. © 2014 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma, Follicular - metabolism</subject><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Adult</subject><subject>Autoantigens - genetics</subject><subject>Autoantigens - metabolism</subject><subject>Female</subject><subject>follicular tumor</subject><subject>Humans</subject><subject>immuocytochemistry</subject><subject>Iodide Peroxidase - genetics</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Iron-Binding Proteins - genetics</subject><subject>Iron-Binding Proteins - metabolism</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - genetics</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Preoperative Period</subject><subject>thyroid</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>thyroid specific peroxidase</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0UuLFDEQAOAgijuugr9AAl689Jp03kcZdX0sK4KPY8gkFc2a6bRJt27_e3sfjuCpoOqroqhC6DElJ5SQ_nnwJz3rCb-DNpQY1RHGzF200UqIjhJmjtCD1i4IIaan8j466gU1Qii6QfmLyzPgEvH0faklBdxG8Ckmj0eo5TIF1wC7IeD3qZMKt8mloeE04LFCWYmb0i_AfplKLt8WHEs9TIol5-Tn7NbUvC-1PUT3ossNHt3GY_T59atP2zfd2YfTt9sXZ13iVPBOCed4T3fKeGEApAzcKNVzzkWIELVXO7KDaAynMWgFQQvnIwQB0nPJNTtGz27mjrX8nKFNdp-ah5zdAGVulkohxHouJlf69D96UeY6rNtdKa611Eas6smtmnd7CHasae_qYv_ecQXdDfidMiyHOiX26j82eHv9H_tyex3_-dQmuDx4V39YqZgS9uv56dryTjKtPtpz9gd7xZDw</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Maruta, Junko</creator><creator>Hashimoto, Hironobu</creator><creator>Yamashita, Hiroto</creator><creator>Noguchi, Hitoshi</creator><creator>Noguchi, Shiro</creator><creator>Kobayashi, Tadao K.</creator><creator>Tsuneoka, Hidehiro</creator><creator>Takahashi, Mutsuo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors</title><author>Maruta, Junko ; Hashimoto, Hironobu ; Yamashita, Hiroto ; Noguchi, Hitoshi ; Noguchi, Shiro ; Kobayashi, Tadao K. ; Tsuneoka, Hidehiro ; Takahashi, Mutsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4154-75aa421b79c59ee66d497724445dfef8c7b0bef9941fd87ed85acfed5e6c46483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma, Follicular - metabolism</topic><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Adult</topic><topic>Autoantigens - genetics</topic><topic>Autoantigens - metabolism</topic><topic>Female</topic><topic>follicular tumor</topic><topic>Humans</topic><topic>immuocytochemistry</topic><topic>Iodide Peroxidase - genetics</topic><topic>Iodide Peroxidase - metabolism</topic><topic>Iron-Binding Proteins - genetics</topic><topic>Iron-Binding Proteins - metabolism</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - genetics</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Preoperative Period</topic><topic>thyroid</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>thyroid specific peroxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruta, Junko</creatorcontrib><creatorcontrib>Hashimoto, Hironobu</creatorcontrib><creatorcontrib>Yamashita, Hiroto</creatorcontrib><creatorcontrib>Noguchi, Hitoshi</creatorcontrib><creatorcontrib>Noguchi, Shiro</creatorcontrib><creatorcontrib>Kobayashi, Tadao K.</creatorcontrib><creatorcontrib>Tsuneoka, Hidehiro</creatorcontrib><creatorcontrib>Takahashi, Mutsuo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruta, Junko</au><au>Hashimoto, Hironobu</au><au>Yamashita, Hiroto</au><au>Noguchi, Hitoshi</au><au>Noguchi, Shiro</au><au>Kobayashi, Tadao K.</au><au>Tsuneoka, Hidehiro</au><au>Takahashi, Mutsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>2015-03</date><risdate>2015</risdate><volume>43</volume><issue>3</issue><spage>202</spage><epage>209</epage><pages>202-209</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Background
The aim of this study was to elucidate immunocytochemically whether thyroid specific peroxidase (TPO) and Ki‐67 can complement fine‐needle aspiration (FNA) cytology as useful markers in order to distinguish between follicular adenoma (FA) and follicular carcinoma (FC).
Methods
We studied 40 FAs and 68 FCs obtained by surgical resection. FNA cytology smears were divided into two groups: Cytology‐A (Cy‐A) (94 cases) with typical benign cytology and Cytology‐B (Cy‐B) (14 cases) with atypical cytology. FCs were divided into two groups: FC‐I (42 cases) without any poorly differentiated structures and FC‐II (26 cases) with some poorly differentiated structures. Cytology smears and histology from FAs and FCs were studied immunocytochemically for thyroid specific peroxidase (TPO) and Ki‐67.
Results
TPO expression was negative in 12.5% FAs, 21.4% FC‐I, and 46.2% FC‐II. In 68 FC cases, Cy‐B were more frequently observed in TPO‐negative cases (38.1%) than in TPO‐positive cases (12.8%). The mean Ki‐67 LI was 0.46 in FAs, 0.53 in FC‐I, and 1.13 in FC‐II. The high Ki‐67 LI was correlated with Cy‐B. Moreover, higher Ki‐67 LI showed a close relationship with distant metastasis. In 94 Cy‐A cases, 54 cases were FCs. When 38 cases with negative TPO or Ki‐67 LI over 0.62 were extracted from them, as many as 28 cases were FCs, the rate of FCs were significantly higher than the rest.
Conclusion
Therefore, addition of TPO stain and Ki‐67 stain to routine Papanicolaou stain could improve the diagnostic reliability of FNA cytology for FC with high degree of malignancy. Diagn. Cytopathol. 2015;43:202–209. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25195571</pmid><doi>10.1002/dc.23204</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma, Follicular - metabolism Adenocarcinoma, Follicular - pathology Adult Autoantigens - genetics Autoantigens - metabolism Female follicular tumor Humans immuocytochemistry Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iron-Binding Proteins - genetics Iron-Binding Proteins - metabolism Ki-67 Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Male Middle Aged Preoperative Period thyroid Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology thyroid specific peroxidase |
| title | Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors |
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