Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry
Summary The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female r...
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| Veröffentlicht in: | Transplant international 2015-03, Vol.28 (3), p.305-313 |
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| creator | Martinez‐Selles, Manuel Almenar, Luis Paniagua‐Martin, Maria J. Segovia, Javier Delgado, Juan F. Arizón, Jose M. Ayesta, Ana Lage, Ernesto Brossa, Vicens Manito, Nicolás Pérez‐Villa, Félix Diaz‐Molina, Beatriz Rábago, Gregorio Blasco‐Peiró, Teresa De La Fuente Galán, Luis Pascual‐Figal, Domingo Gonzalez‐Vilchez, Francisco |
| description | Summary
The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P |
| doi_str_mv | 10.1111/tri.12488 |
| format | Article |
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The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long‐term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.12488</identifier><identifier>PMID: 25399778</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Female ; gender ; heart transplantation ; Heart Transplantation - mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; mismatch ; Registries ; Retrospective Studies ; sex ; Sex Factors ; Spain - epidemiology ; Survival Rate - trends ; Tissue and Organ Procurement - methods ; Transplant Recipients ; Young Adult</subject><ispartof>Transplant international, 2015-03, Vol.28 (3), p.305-313</ispartof><rights>2014 Steunstichting ESOT</rights><rights>2014 Steunstichting ESOT.</rights><rights>Copyright © 2015 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-da7aaf25bf5fedc6783b4d662aa6f5ed65ff2f9ed119721ad9ef31fb06b805393</citedby><cites>FETCH-LOGICAL-c3538-da7aaf25bf5fedc6783b4d662aa6f5ed65ff2f9ed119721ad9ef31fb06b805393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.12488$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.12488$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25399778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinez‐Selles, Manuel</creatorcontrib><creatorcontrib>Almenar, Luis</creatorcontrib><creatorcontrib>Paniagua‐Martin, Maria J.</creatorcontrib><creatorcontrib>Segovia, Javier</creatorcontrib><creatorcontrib>Delgado, Juan F.</creatorcontrib><creatorcontrib>Arizón, Jose M.</creatorcontrib><creatorcontrib>Ayesta, Ana</creatorcontrib><creatorcontrib>Lage, Ernesto</creatorcontrib><creatorcontrib>Brossa, Vicens</creatorcontrib><creatorcontrib>Manito, Nicolás</creatorcontrib><creatorcontrib>Pérez‐Villa, Félix</creatorcontrib><creatorcontrib>Diaz‐Molina, Beatriz</creatorcontrib><creatorcontrib>Rábago, Gregorio</creatorcontrib><creatorcontrib>Blasco‐Peiró, Teresa</creatorcontrib><creatorcontrib>De La Fuente Galán, Luis</creatorcontrib><creatorcontrib>Pascual‐Figal, Domingo</creatorcontrib><creatorcontrib>Gonzalez‐Vilchez, Francisco</creatorcontrib><creatorcontrib>Spanish Registry of Heart Transplantation</creatorcontrib><creatorcontrib>the Spanish Registry of Heart Transplantation</creatorcontrib><title>Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long‐term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>gender</subject><subject>heart transplantation</subject><subject>Heart Transplantation - mortality</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mismatch</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>sex</subject><subject>Sex Factors</subject><subject>Spain - epidemiology</subject><subject>Survival Rate - trends</subject><subject>Tissue and Organ Procurement - methods</subject><subject>Transplant Recipients</subject><subject>Young Adult</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhi0EoofCghdAltjAIj2-xI7DBlXl0kqVkMphHU2SMcdV4gTbKeR1eFJMT6kEErOZxXz6NDM_Ic85O-G5tim4Ey5KYx6QDS-lKISoqodkw2pZFsxU5RF5EuM1Y0wYxR6TI6FkXVeV2ZCf7yY_hW3Azs0OfaIRf9DRxRFSt6fgexqXcONuYKBgEwa6RwiJpgA-zgP4BMlN_g2d_LBmnLoYF6TO0xEGpPfa-Jae-jyHYY0u0snStEf6eQbv4p6e3zp3fzvpFX51MYX1KXlkYYj47K4fky8f3u_OzovLTx8vzk4vi04qaYoeKgArVGuVxb7TlZFt2WstALRV2GtlrbA19pzXleDQ12glty3TrWH5H_KYvDp45zB9WzCmJv-hwyFvhNMSG66VUoJJqTP68h_0elpCvi5TldY1U0ayTL0-UF2YYgxomzm4EcLacNb8Dq7JwTW3wWX2xZ1xaUfs78k_SWVgewC-uwHX_5ua3dXFQfkL6YumXg</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Martinez‐Selles, Manuel</creator><creator>Almenar, Luis</creator><creator>Paniagua‐Martin, Maria J.</creator><creator>Segovia, Javier</creator><creator>Delgado, Juan F.</creator><creator>Arizón, Jose M.</creator><creator>Ayesta, Ana</creator><creator>Lage, Ernesto</creator><creator>Brossa, Vicens</creator><creator>Manito, Nicolás</creator><creator>Pérez‐Villa, Félix</creator><creator>Diaz‐Molina, Beatriz</creator><creator>Rábago, Gregorio</creator><creator>Blasco‐Peiró, Teresa</creator><creator>De La Fuente Galán, Luis</creator><creator>Pascual‐Figal, Domingo</creator><creator>Gonzalez‐Vilchez, Francisco</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry</title><author>Martinez‐Selles, Manuel ; Almenar, Luis ; Paniagua‐Martin, Maria J. ; Segovia, Javier ; Delgado, Juan F. ; Arizón, Jose M. ; Ayesta, Ana ; Lage, Ernesto ; Brossa, Vicens ; Manito, Nicolás ; Pérez‐Villa, Félix ; Diaz‐Molina, Beatriz ; Rábago, Gregorio ; Blasco‐Peiró, Teresa ; De La Fuente Galán, Luis ; Pascual‐Figal, Domingo ; Gonzalez‐Vilchez, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-da7aaf25bf5fedc6783b4d662aa6f5ed65ff2f9ed119721ad9ef31fb06b805393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>gender</topic><topic>heart transplantation</topic><topic>Heart Transplantation - mortality</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mismatch</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>sex</topic><topic>Sex Factors</topic><topic>Spain - epidemiology</topic><topic>Survival Rate - trends</topic><topic>Tissue and Organ Procurement - methods</topic><topic>Transplant Recipients</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez‐Selles, Manuel</creatorcontrib><creatorcontrib>Almenar, Luis</creatorcontrib><creatorcontrib>Paniagua‐Martin, Maria J.</creatorcontrib><creatorcontrib>Segovia, Javier</creatorcontrib><creatorcontrib>Delgado, Juan F.</creatorcontrib><creatorcontrib>Arizón, Jose M.</creatorcontrib><creatorcontrib>Ayesta, Ana</creatorcontrib><creatorcontrib>Lage, Ernesto</creatorcontrib><creatorcontrib>Brossa, Vicens</creatorcontrib><creatorcontrib>Manito, Nicolás</creatorcontrib><creatorcontrib>Pérez‐Villa, Félix</creatorcontrib><creatorcontrib>Diaz‐Molina, Beatriz</creatorcontrib><creatorcontrib>Rábago, Gregorio</creatorcontrib><creatorcontrib>Blasco‐Peiró, Teresa</creatorcontrib><creatorcontrib>De La Fuente Galán, Luis</creatorcontrib><creatorcontrib>Pascual‐Figal, Domingo</creatorcontrib><creatorcontrib>Gonzalez‐Vilchez, Francisco</creatorcontrib><creatorcontrib>Spanish Registry of Heart Transplantation</creatorcontrib><creatorcontrib>the Spanish Registry of Heart Transplantation</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez‐Selles, Manuel</au><au>Almenar, Luis</au><au>Paniagua‐Martin, Maria J.</au><au>Segovia, Javier</au><au>Delgado, Juan F.</au><au>Arizón, Jose M.</au><au>Ayesta, Ana</au><au>Lage, Ernesto</au><au>Brossa, Vicens</au><au>Manito, Nicolás</au><au>Pérez‐Villa, Félix</au><au>Diaz‐Molina, Beatriz</au><au>Rábago, Gregorio</au><au>Blasco‐Peiró, Teresa</au><au>De La Fuente Galán, Luis</au><au>Pascual‐Figal, Domingo</au><au>Gonzalez‐Vilchez, Francisco</au><aucorp>Spanish Registry of Heart Transplantation</aucorp><aucorp>the Spanish Registry of Heart Transplantation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2015-03</date><risdate>2015</risdate><volume>28</volume><issue>3</issue><spage>305</spage><epage>313</epage><pages>305-313</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long‐term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25399778</pmid><doi>10.1111/tri.12488</doi><tpages>9</tpages></addata></record> |
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| ispartof | Transplant international, 2015-03, Vol.28 (3), p.305-313 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Female gender heart transplantation Heart Transplantation - mortality Humans Kaplan-Meier Estimate Male Middle Aged mismatch Registries Retrospective Studies sex Sex Factors Spain - epidemiology Survival Rate - trends Tissue and Organ Procurement - methods Transplant Recipients Young Adult |
| title | Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry |
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