Ribonuclease A Variants with Potent Cytotoxic Activity

Select members of the bovine pancreatic ribonuclease A (RNase A) superfamily are potent cytotoxins. These cytotoxic ribonucleases enter the cytosol, where they degrade cellular RNA and cause cell death. Ribonuclease inhibitor (RI), a cytosolic protein, binds to members of the RNase A superfamily wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-09, Vol.95 (18), p.10407-10412
Hauptverfasser:	Leland, Peter A., Schultz, L. Wayne, Kim, Byung-Moon, Raines, Ronald T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biochemistry Biological Sciences Cattle Cell lines Cell Survival - drug effects Complementary DNA Cytotoxicity DNA Enzyme Inhibitors - pharmacology Enzyme Stability Enzymes Kinetics Pancreas Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - chemistry Recombinant Proteins - pharmacology Ribonuclease, Pancreatic - antagonists & inhibitors Ribonuclease, Pancreatic - chemistry Ribonuclease, Pancreatic - pharmacology RNA Thermal stability Tumor Cells, Cultured Ungulates
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