Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine
The behavioral and neurochemical effects of NEI, and its interaction with α-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 μl/side). NEI in the VMN (but not in the MPOA) stimulated exploratory beh...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998-01, Vol.19 (6), p.1007-1016 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Gonzalez, M.I Baker, B.I Hole, D.R Wilson, C.A |
| description | The behavioral and neurochemical effects of NEI, and its interaction with α-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 μl/side). NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by α-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation. |
| doi_str_mv | 10.1016/S0196-9781(98)00045-X |
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NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by α-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/S0196-9781(98)00045-X</identifier><identifier>PMID: 9700748</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Agonistic behavior ; alpha-MSH - pharmacology ; Animals ; Anxiety ; Behavior, Animal - drug effects ; Dopamine - metabolism ; Dopamine - pharmacology ; Drug Interactions ; Exploration ; Exploratory Behavior - drug effects ; Female ; Hypothalamic Hormones - pharmacology ; Maze Learning - drug effects ; Medial preoptic area (MPOA) ; Melanin concentrating hormone (MCH) ; Melanins - pharmacology ; Melanophores - metabolism ; Neuropeptide E-I (NEI) ; Peptide Fragments - pharmacology ; Pituitary Hormones - pharmacology ; Posture ; Preoptic Area - drug effects ; Preoptic Area - metabolism ; Rats ; Serotonin (5-HT) ; Serotonin - metabolism ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Ventromedial Hypothalamic Nucleus - drug effects ; Ventromedial Hypothalamic Nucleus - metabolism ; Ventromedial nucleus (VMN) ; α-Melanocyte stimulating hormone (α-MSH)</subject><ispartof>Peptides (New York, N.Y. : 1980), 1998-01, Vol.19 (6), p.1007-1016</ispartof><rights>1998 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f9fa141dff22e43e992adf67e21e6e043f098e4cca9831f0920b793d1fad56713</citedby><cites>FETCH-LOGICAL-c391t-f9fa141dff22e43e992adf67e21e6e043f098e4cca9831f0920b793d1fad56713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019697819800045X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9700748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez, M.I</creatorcontrib><creatorcontrib>Baker, B.I</creatorcontrib><creatorcontrib>Hole, D.R</creatorcontrib><creatorcontrib>Wilson, C.A</creatorcontrib><title>Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The behavioral and neurochemical effects of NEI, and its interaction with α-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 μl/side). NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by α-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Agonistic behavior</subject><subject>alpha-MSH - pharmacology</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior, Animal - drug effects</subject><subject>Dopamine - metabolism</subject><subject>Dopamine - pharmacology</subject><subject>Drug Interactions</subject><subject>Exploration</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Hypothalamic Hormones - pharmacology</subject><subject>Maze Learning - drug effects</subject><subject>Medial preoptic area (MPOA)</subject><subject>Melanin concentrating hormone (MCH)</subject><subject>Melanins - pharmacology</subject><subject>Melanophores - metabolism</subject><subject>Neuropeptide E-I (NEI)</subject><subject>Peptide Fragments - pharmacology</subject><subject>Pituitary Hormones - pharmacology</subject><subject>Posture</subject><subject>Preoptic Area - drug effects</subject><subject>Preoptic Area - metabolism</subject><subject>Rats</subject><subject>Serotonin (5-HT)</subject><subject>Serotonin - metabolism</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Ventromedial Hypothalamic Nucleus - drug effects</subject><subject>Ventromedial Hypothalamic Nucleus - metabolism</subject><subject>Ventromedial nucleus (VMN)</subject><subject>α-Melanocyte stimulating hormone (α-MSH)</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKBDEQRYMoOj4-QchKFGxN-pm4ER1GZ8DRhQruQkwqTKS70yYZxc_yR_wmex64dVVU3Vt1qYPQISVnlNDy_JFQXia8YvSYsxNCSF4kLxtoQFmVJQUt-SYa_Fl20G4IbwtTztk22uYVIVXOBujtGmbywzovawzGgIoBO4NbmHvXQRetBjxKJvj4fjQ5wbbFcQbYQCNrwF7Gi34UwUsVrWsD_rRxhn--k-nj-BRPh2MsW42162RjW9hHW0bWAQ7WdQ8934yehuPk7uF2Mry6S1TGaUwMN5LmVBuTppBnwHkqtSkrSCmUQPLMEM4gV0pyltG-SclrxTNNjdRFWdFsDx2t7nbevc8hRNHYoKCuZQtuHgQtiyLLK9Ybi5VReReCByM6bxvpvwQlYsFYLBmLBUDBmVgyFi_93uE6YP7agP7bWkPt9cuVDv2XHxa8CMpCq0Bb3wMW2tl_En4BGRSLhQ</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Gonzalez, M.I</creator><creator>Baker, B.I</creator><creator>Hole, D.R</creator><creator>Wilson, C.A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>19980101</creationdate><title>Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine</title><author>Gonzalez, M.I ; Baker, B.I ; Hole, D.R ; Wilson, C.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f9fa141dff22e43e992adf67e21e6e043f098e4cca9831f0920b793d1fad56713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Agonistic behavior</topic><topic>alpha-MSH - pharmacology</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Behavior, Animal - drug effects</topic><topic>Dopamine - metabolism</topic><topic>Dopamine - pharmacology</topic><topic>Drug Interactions</topic><topic>Exploration</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Hypothalamic Hormones - pharmacology</topic><topic>Maze Learning - drug effects</topic><topic>Medial preoptic area (MPOA)</topic><topic>Melanin concentrating hormone (MCH)</topic><topic>Melanins - pharmacology</topic><topic>Melanophores - metabolism</topic><topic>Neuropeptide E-I (NEI)</topic><topic>Peptide Fragments - pharmacology</topic><topic>Pituitary Hormones - pharmacology</topic><topic>Posture</topic><topic>Preoptic Area - drug effects</topic><topic>Preoptic Area - metabolism</topic><topic>Rats</topic><topic>Serotonin (5-HT)</topic><topic>Serotonin - metabolism</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Ventromedial Hypothalamic Nucleus - drug effects</topic><topic>Ventromedial Hypothalamic Nucleus - metabolism</topic><topic>Ventromedial nucleus (VMN)</topic><topic>α-Melanocyte stimulating hormone (α-MSH)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez, M.I</creatorcontrib><creatorcontrib>Baker, B.I</creatorcontrib><creatorcontrib>Hole, D.R</creatorcontrib><creatorcontrib>Wilson, C.A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez, M.I</au><au>Baker, B.I</au><au>Hole, D.R</au><au>Wilson, C.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>19</volume><issue>6</issue><spage>1007</spage><epage>1016</epage><pages>1007-1016</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>The behavioral and neurochemical effects of NEI, and its interaction with α-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 μl/side). NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by α-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9700748</pmid><doi>10.1016/S0196-9781(98)00045-X</doi><tpages>10</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 1998-01, Vol.19 (6), p.1007-1016 |
| issn | 0196-9781 1873-5169 |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Agonistic behavior alpha-MSH - pharmacology Animals Anxiety Behavior, Animal - drug effects Dopamine - metabolism Dopamine - pharmacology Drug Interactions Exploration Exploratory Behavior - drug effects Female Hypothalamic Hormones - pharmacology Maze Learning - drug effects Medial preoptic area (MPOA) Melanin concentrating hormone (MCH) Melanins - pharmacology Melanophores - metabolism Neuropeptide E-I (NEI) Peptide Fragments - pharmacology Pituitary Hormones - pharmacology Posture Preoptic Area - drug effects Preoptic Area - metabolism Rats Serotonin (5-HT) Serotonin - metabolism Sexual behavior Sexual Behavior, Animal - drug effects Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - metabolism Ventromedial nucleus (VMN) α-Melanocyte stimulating hormone (α-MSH) |
| title | Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine |
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