Apico-basal forces exerted by apoptotic cells drive epithelium folding

Apoptotic cell death is required for morphogenesis of the developing leg joint of fruitflies; using this model system, the authors show here that within apoptotic cells a transient pulling force exerted through a highly dynamic apico-basal myosin II cable-like structure acts as a mechanical signal t...

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Veröffentlicht in:	Nature (London) 2015-02, Vol.518 (7538), p.245-248
Hauptverfasser:	Monier, Bruno, Gettings, Melanie, Gay, Guillaume, Mangeat, Thomas, Schott, Sonia, Guarner, Ana, Suzanne, Magali
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/1660 631/80/128/1675 631/80/82/23 Adherens Junctions - chemistry Adherens Junctions - metabolism Animals Apoptosis Cell Polarity Cell research Cell Shape Cells Cytoskeleton Drosophila melanogaster - cytology Drosophila melanogaster - embryology Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium Epithelium - embryology Humanities and Social Sciences letter Models, Biological Morphogenesis multidisciplinary Myosin Type II - metabolism Observations Physiological aspects Science Tissues
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