Effect of Size and N‑Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7

Bac7 is a proline-rich antimicrobial peptide, selective for Gram-negative bacteria, which acts intracellularly after membrane translocation. Progressively shortened fragments of Bac7 allowed determining the minimal sequence required for entry and antimicrobial activity as a 16-residue, N-terminal fr...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-02, Vol.58 (3), p.1195-1204
Hauptverfasser:	Guida, Filomena, Benincasa, Monica, Zahariev, Sotir, Scocchi, Marco, Berti, Federico, Gennaro, Renato, Tossi, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Dose-Response Relationship, Drug Escherichia coli - cytology Escherichia coli - drug effects Escherichia coli - growth & development Microbial Sensitivity Tests Molecular Structure Monte Carlo Method Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Structure-Activity Relationship
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