Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase Open New Prospects for the Treatment of Neurological Disorders

The disubstituted pyrimidines based SAR study by Silverman et al. ( J. Med. Chem. 2014, DOI: 10.1021/jm501719e) was focused on improving bioavailability and physicochemical properties of the designed inhibitors while retaining the potency for neural nitric oxide synthase (nNOS) and selectivity over...

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