Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and Spread

The spread of intra-abdominal cancers is a vexing clinical problem for which there is no widely effective treatment. We discovered previously that (2E)-3-[(4-tert-butylphenyl)sulfonyl]acrylonitrile (1) induced cancer cell apoptosis during adhesion to normal mesothelial cells which line the periton...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-02, Vol.58 (3), p.1140-1158
Hauptverfasser:	Shen, Yi, Zificsak, Craig A, Shea, Jill E, Lao, Xuegang, Bollt, Oana, Li, Xiufen, Lisko, Joseph G, Theroff, Jay P, Scaife, Courtney L, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D, Kuwada, Scott K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylonitrile - chemical synthesis Acrylonitrile - chemistry Acrylonitrile - pharmacology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Design Female HT29 Cells Humans Mice Molecular Structure Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - secondary Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - secondary Structure-Activity Relationship Sulfones - chemical synthesis Sulfones - chemistry Sulfones - pharmacology
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