Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays

Medicinal chemists have been encouraged in recent years to embrace high speed protein binding assays. These methods employ dialysis membranes in 96-well format or spin filters. Membrane-based methods do not separate lipoprotein binding from albumin binding and introduce interference despite membrane...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-02, Vol.58 (3), p.1420-1425
Hauptverfasser:	Brockman, Adam H, Oller, Haley R, Moreau, Benoît, Kriksciukaite, Kristina, Bilodeau, Mark T
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - chemistry Bridged-Ring Compounds - chemistry Chemistry, Pharmaceutical Dialysis Lipoproteins - chemistry Molecular Structure Organoplatinum Compounds - chemistry Protein Binding Taxoids - chemistry Ultracentrifugation
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