[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain

Purpose We aimed to characterize pharmacologically the TSPO- radioligand [ 18 F]DPA-714 in the brain of healthy cynomolgus monkeys and evaluate the cellular origin of its binding in a model of neurodegeneration induced by intrastriatal injection of quinolinic acid (QA). Methods [ 18 F]DPA-714 PET im...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2015-03, Vol.42 (3), p.478-494
Hauptverfasser:	Lavisse, S., Inoue, K., Jan, C., Peyronneau, M. A., Petit, F., Goutal, S., Dauguet, J., Guillermier, M., Dollé, F., Rbah-Vidal, L., Van Camp, N., Aron-Badin, R., Remy, P., Hantraye, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Brain - diagnostic imaging Cardiology Fluorine Radioisotopes - pharmacokinetics Imaging Macaca fascicularis Male Medicine Medicine & Public Health Nuclear Medicine Oncology Original Article Orthopedics Pharmacology Positron-Emission Tomography Primates Proteins Pyrazoles - pharmacokinetics Pyrimidines - pharmacokinetics Radiology Radiopharmaceuticals - pharmacokinetics Receptors, GABA-A - metabolism Tissue Distribution Tomography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!