Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats

The Kv7 family of voltage-gated potassium channels are expressed within the vasculature where they are key regulators of vascular tone and mediate cAMP-linked endogenous vasodilator responses, a pathway that is compromised in hypertension. However, the role of Kv7 channels in non-cAMP-linked vasodil...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-03, Vol.65 (3), p.676-682
Hauptverfasser:	Stott, Jennifer B, Barrese, Vincenzo, Jepps, Thomas A, Leighton, Emma V, Greenwood, Iain A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - physiopathology Chromans - pharmacology Cyclic GMP - physiology Disease Models, Animal Hypertension - physiopathology Indoles - pharmacology KCNQ Potassium Channels - physiology KCNQ1 Potassium Channel - physiology Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Natriuretic Peptides - pharmacology Nitroprusside - pharmacology Potassium Channel Blockers - pharmacology Pyridines - pharmacology Rats Rats, Inbred SHR Rats, Wistar Renal Artery - drug effects Renal Artery - physiopathology Signal Transduction - physiology Sulfonamides - pharmacology Vasodilation - drug effects Vasodilation - physiology
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