Identification of Functional Domains of the Human Glutamate Transporters EAAT1 and EAAT2

Glutamate transporters serve the important function of mediating removal of glutamate released at excitatory synapses and maintaining extracellular concentrations below excitotoxic levels. Excitatory amino acid transporter subtypes EAAT1 and EAAT2 have a high degree of sequence homology and similar...

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Veröffentlicht in:	The Journal of biological chemistry 1998-06, Vol.273 (24), p.14698-14706
Hauptverfasser:	Mitrovic, Ann D., Amara, Susan G., Johnston, Graham A.R., Vandenberg, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Transport System X-AG Animals Aspartic Acid - pharmacology ATP-Binding Cassette Transporters Biological Transport - physiology Electrophysiology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Transporter 2 Gene Expression - genetics Glutamates - pharmacology Glutamic Acid - pharmacokinetics Humans Kainic Acid - pharmacology Molecular Sequence Data Oocytes - metabolism Patch-Clamp Techniques Receptors, Neurotransmitter - chemistry Recombinant Fusion Proteins - chemistry Recombinant Proteins - chemistry Sequence Alignment Serine - analogs & derivatives Serine - pharmacology Xenopus laevis
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