Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

: Two membrane glycoproteins acting as energy‐dependent efflux pumps, mdr‐encoded P‐glycoprotein (P‐gp) and the more recently described multidrug resistance‐associated protein (MRP), are known to confer cellular resistance to many cytotoxic hydrophobic drugs. In the brain, P‐gp has been shown to be...

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Veröffentlicht in:	Journal of neurochemistry 1998-08, Vol.71 (2), p.705-715
Hauptverfasser:	Regina, Anthony, Koman, Ahmet, Piciotti, Michèle, El Hafny, Bouchra, Center, Melvin S., Bergmann, Ralf, Couraud, Pierre‐Olivier, Roux, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacokinetics Astrocytes - cytology Astrocytes - physiology ATP Binding Cassette Transporter, Subfamily B, Member 1 - analysis ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Benzbromarone - pharmacology Biological and medical sciences Blood‐brain barrier Brain - blood supply Capillaries - chemistry Capillaries - physiology Carcinogens - pharmacology Cell Line, Transformed - chemistry Cell Line, Transformed - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Colchicine - pharmacokinetics Cyclosporine - pharmacology DNA-Binding Proteins - analysis DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics Endothelium, Vascular - chemistry Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Genistein - pharmacology Gout Suppressants - pharmacokinetics Immunoblotting Multidrug Resistance-Associated Proteins Multidrug resistance‐associated protein MutS Homolog 3 Protein Polymerase Chain Reaction Primary cell culture Probenecid - pharmacology P‐glycoprotein Rat brain microvessel endothelium Rats Rats, Sprague-Dawley RBE4 cells RNA, Messenger - metabolism Sulfinpyrazone - pharmacology Uricosuric Agents - pharmacology Vertebrates: nervous system and sense organs Vinblastine - pharmacokinetics Vincristine - pharmacokinetics
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