Different sensitivities to paraoxon of brain and serum cholinesterases from Pacu, an indigenous Brazilian fish
In pacu, Piaractus mesopotamicus, which is an economically important fish in Brazil, the response of serum and brain cholinesterase activity to paraoxon was investigated. Paraoxon results from parathion bioactivation. Results showed that paraoxon concentrations five times lower than those used to pr...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1998-01, Vol.60 (1), p.1-8 |
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| creator | Cunha Bastos, V.L.F. (Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.) Rossini, A Ribeiro Pinto, L.F Lima, L.M. de Ceccarelli, P.S Coelho, M.G.P Cunha Bastos, J |
| description | In pacu, Piaractus mesopotamicus, which is an economically important fish in Brazil, the response of serum and brain cholinesterase activity to paraoxon was investigated. Paraoxon results from parathion bioactivation. Results showed that paraoxon concentrations five times lower than those used to produce inhibition of brain cholinesterase activities were able to produce nearly total inhibition of serum activities. The I sub(50) values for brain acetylcholinesterase and serum butylcholinesterase were calculated at 254 and 1.8 nM, respectively. In vitro inhibition curves showed that either of the butylcholinesterase determinations, using brain or serum, accurately detected paraoxon concentrations under the detection limit of gas chromatography. |
| doi_str_mv | 10.1007/s001289900583 |
| format | Article |
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(Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.) ; Rossini, A ; Ribeiro Pinto, L.F ; Lima, L.M. de ; Ceccarelli, P.S ; Coelho, M.G.P ; Cunha Bastos, J</creator><creatorcontrib>Cunha Bastos, V.L.F. (Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.) ; Rossini, A ; Ribeiro Pinto, L.F ; Lima, L.M. de ; Ceccarelli, P.S ; Coelho, M.G.P ; Cunha Bastos, J</creatorcontrib><description>In pacu, Piaractus mesopotamicus, which is an economically important fish in Brazil, the response of serum and brain cholinesterase activity to paraoxon was investigated. Paraoxon results from parathion bioactivation. Results showed that paraoxon concentrations five times lower than those used to produce inhibition of brain cholinesterase activities were able to produce nearly total inhibition of serum activities. The I sub(50) values for brain acetylcholinesterase and serum butylcholinesterase were calculated at 254 and 1.8 nM, respectively. In vitro inhibition curves showed that either of the butylcholinesterase determinations, using brain or serum, accurately detected paraoxon concentrations under the detection limit of gas chromatography.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s001289900583</identifier><identifier>PMID: 9484549</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Agnatha. 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Psychology ; Insecticides - toxicity ; NONTARGET ORGANISMS ; Paraoxon - toxicity ; PECES ; Piaractus mesopotamicus ; POISSON (ANIMAL) ; Water Pollutants, Chemical - toxicity</subject><ispartof>Bulletin of environmental contamination and toxicology, 1998-01, Vol.60 (1), p.1-8</ispartof><rights>1998 INIST-CNRS</rights><rights>Springer-Verlag New York Inc. 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-3ecf0febc5faa1c60a36254e2afa7eac61d914f7516a0ba38fd34f88e43449523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2147367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9484549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunha Bastos, V.L.F. (Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.)</creatorcontrib><creatorcontrib>Rossini, A</creatorcontrib><creatorcontrib>Ribeiro Pinto, L.F</creatorcontrib><creatorcontrib>Lima, L.M. de</creatorcontrib><creatorcontrib>Ceccarelli, P.S</creatorcontrib><creatorcontrib>Coelho, M.G.P</creatorcontrib><creatorcontrib>Cunha Bastos, J</creatorcontrib><title>Different sensitivities to paraoxon of brain and serum cholinesterases from Pacu, an indigenous Brazilian fish</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>In pacu, Piaractus mesopotamicus, which is an economically important fish in Brazil, the response of serum and brain cholinesterase activity to paraoxon was investigated. Paraoxon results from parathion bioactivation. Results showed that paraoxon concentrations five times lower than those used to produce inhibition of brain cholinesterase activities were able to produce nearly total inhibition of serum activities. The I sub(50) values for brain acetylcholinesterase and serum butylcholinesterase were calculated at 254 and 1.8 nM, respectively. In vitro inhibition curves showed that either of the butylcholinesterase determinations, using brain or serum, accurately detected paraoxon concentrations under the detection limit of gas chromatography.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>BRASIL</subject><subject>BRAZIL</subject><subject>BRESIL</subject><subject>Butyrylcholinesterase - metabolism</subject><subject>Cholinesterase Inhibitors - toxicity</subject><subject>Cholinesterases - blood</subject><subject>Cholinesterases - metabolism</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Environmental Monitoring</subject><subject>FISHES</subject><subject>Fishes - metabolism</subject><subject>Fundamental and applied biological sciences. 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(Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.)</au><au>Rossini, A</au><au>Ribeiro Pinto, L.F</au><au>Lima, L.M. de</au><au>Ceccarelli, P.S</au><au>Coelho, M.G.P</au><au>Cunha Bastos, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different sensitivities to paraoxon of brain and serum cholinesterases from Pacu, an indigenous Brazilian fish</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>60</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>In pacu, Piaractus mesopotamicus, which is an economically important fish in Brazil, the response of serum and brain cholinesterase activity to paraoxon was investigated. Paraoxon results from parathion bioactivation. Results showed that paraoxon concentrations five times lower than those used to produce inhibition of brain cholinesterase activities were able to produce nearly total inhibition of serum activities. The I sub(50) values for brain acetylcholinesterase and serum butylcholinesterase were calculated at 254 and 1.8 nM, respectively. In vitro inhibition curves showed that either of the butylcholinesterase determinations, using brain or serum, accurately detected paraoxon concentrations under the detection limit of gas chromatography.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>9484549</pmid><doi>10.1007/s001289900583</doi><tpages>8</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 1998-01, Vol.60 (1), p.1-8 |
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| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Brain - drug effects Brain - enzymology BRASIL BRAZIL BRESIL Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - toxicity Cholinesterases - blood Cholinesterases - metabolism Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environmental Monitoring FISHES Fishes - metabolism Fundamental and applied biological sciences. Psychology Insecticides - toxicity NONTARGET ORGANISMS Paraoxon - toxicity PECES Piaractus mesopotamicus POISSON (ANIMAL) Water Pollutants, Chemical - toxicity |
| title | Different sensitivities to paraoxon of brain and serum cholinesterases from Pacu, an indigenous Brazilian fish |
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