Ammonia potentiates GABA sub(A) response in dissociated rat cortical neurons

Ammonia potentiates GABA sub(A) response in dissociated rat cortical neurons

The ammonium ion (NH sub(4) super(+)) evoked no response itself but facilitated the GABA-induced Cl super(-) current (I sub(Cl)) in dissociated rat cortical neurons. The GABA concentration-response curve shifted parallely to the left without changing the maximum response. Reversal potential of GABA...

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Veröffentlicht in:Neuroscience letters 1993-01, Vol.151 (1), p.51-54
Hauptverfasser: Takahashi, K, Kameda, H, Kataoka, M, Sanjou, K, Harata, N, Akaike, N
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ammonia
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container_title Neuroscience letters
container_volume 151
creator Takahashi, K
Kameda, H
Kataoka, M
Sanjou, K
Harata, N
Akaike, N
description The ammonium ion (NH sub(4) super(+)) evoked no response itself but facilitated the GABA-induced Cl super(-) current (I sub(Cl)) in dissociated rat cortical neurons. The GABA concentration-response curve shifted parallely to the left without changing the maximum response. Reversal potential of GABA response did not change in the presence of NH sub(4) super(+) at the concentration range between 0.1 and 1 mM. Ro 15-1788, a selective benzodiazepine receptor antagonist, did not affect the facilitatory action of NH sub(4) super(+) on GABA sub(A) receptor. The results suggest that NH sub(4) super(+) modifies the affinity of GABA sub(A) receptor for GABA, without the involvement of benzodiazepine receptors.
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title Ammonia potentiates GABA sub(A) response in dissociated rat cortical neurons
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