Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile

2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-01, Vol.13 (8), p.2247-2250
Hauptverfasser:	Adili, Alafate, Tao, Zhong-Lin, Chen, Dian-Feng, Han, Zhi-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzopyrans - chemical synthesis Benzopyrans - chemistry Catalysis Cyclization Indolequinones - chemistry Molecular Structure Nitriles - chemistry Quinine - chemistry Stereoisomerism
Online-Zugang:	Volltext
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