HAb18G/CD147 promotes radioresistance in hepatocellular carcinoma cells: a potential role for integrin β1 signaling

Radiotherapy has played a limited role in the treatment of hepatocellular carcinoma (HCC) due to the risk of tumor radioresistance. A previous study in our laboratory confirmed that CD147 interacts with integrin β1 and plays an important role in modulating the malignant properties of HCC cells. In t...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-02, Vol.14 (2), p.553-563
Hauptverfasser:	Wu, Jiao, Li, Yong, Dang, Ya-Zheng, Gao, Hong-Xiang, Jiang, Jian-Li, Chen, Zhi-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basigin - metabolism Carcinogenesis - pathology Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Movement Cell Survival Gene Deletion Hep G2 Cells Humans Integrin beta1 - metabolism Liver Neoplasms - blood supply Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Neovascularization, Pathologic - metabolism Radiation Tolerance Signal Transduction Tumor Stem Cell Assay Up-Regulation X-Rays Xenograft Model Antitumor Assays
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