Probucol Prevents Atrial Remodeling by Inhibiting Oxidative Stress and TNF-α/NF-κB/TGF-β Signal Transduction Pathway in Alloxan-Induced Diabetic Rabbits

Probucol Prevents Atrial Remodeling Introduction Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). However, the underlying mechanisms for the increased propensity for AF in the setting of DM and the potential effects of probucol on atrial remodeling remain unclear. M...

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Veröffentlicht in:	Journal of cardiovascular electrophysiology 2015-02, Vol.26 (2), p.211-222
Hauptverfasser:	FU, HUAYING, LI, GUANGPING, LIU, CHANGLE, LI, JIAN, WANG, XINGHUA, CHENG, LIJUN, LIU, TONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - etiology Atrial Fibrillation - genetics Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Atrial Fibrillation - prevention & control Atrial Remodeling - drug effects Biomarkers - blood diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diagnosis Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Fibrosis Gene Expression Regulation Heart Atria - drug effects Heart Atria - metabolism Heart Atria - pathology Heart Atria - physiopathology inflammation Inflammation Mediators - metabolism NF-kappa B - metabolism oxidative stress Oxidative Stress - drug effects probucol Probucol - pharmacology Rabbits remodeling RNA, Messenger - metabolism Signal Transduction - drug effects signal transduction pathway Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor Necrosis Factor-alpha - metabolism
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