Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes
Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in th...
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| Veröffentlicht in: | Journal of human hypertension 2015-03, Vol.29 (3), p.185-189 |
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| creator | Major, RW Davies, MJ Crasto, W Gray, LJ Webb, DR Khunti, K |
| description | Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in the ADDITION-Leicester study, a UK based multiethnic, community diabetes screening study. Standard definitions included: HTN—mean recorded BP of ⩾140/90 mm Hg, CKD stage 3 and above—estimated glomerular filtration rate (eGFR) |
| doi_str_mv | 10.1038/jhh.2014.62 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1654700226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A403448807</galeid><sourcerecordid>A403448807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-922267acc82ab7fe5d6286eafe7f77c75852a40d15ac6e6990a7b4334e86982c3</originalsourceid><addsrcrecordid>eNp9kk2LFDEQhoMo7uzqybsEBBF0xiSdrz4Oi6vCggf1HNLp6umM3cmYdDPsvzfNrLori-QQknryVlXqRegFJRtKKv1-3_cbRijfSPYIrShXci0EU4_RitSCrGvGyRk6z3lPyBLUT9EZE5TWWssV6rc5R-ft5GPADUxHgIDn0Hq7CzFDi_ubA6QJQl4AG1o8epeiHZp59GFO3mIf8Nc4Tz3eZm9Dxkc_9eWMf4R4DLgoFVnIz9CTzg4Znt_uF-j71Ydvl5_W118-fr7cXq-d0Goq1TImlXVOM9uoDkQrmZZgO1CdUk4JLZjlpKXCOgmyrolVDa8qDlrWmrnqAr056R5S_DlDnszos4NhsAHinA2VgitCSpaCvvoH3cc5hVKdYVVFJSWkJv-jilZFGZVE_6V2dgDjQxenZN2S2mw5qTjXmqhCbR6gymqhfGsM0Plyf-_B6zsPerDD1Oc4zMu48n3w7Qksw8k5QWcOyY823RhKzGITU2xiFpsYyQr98ranuRmh_cP-9kUB3p2AXEJhB-lO0w_o_QJmvsSh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1653121608</pqid></control><display><type>article</type><title>Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Major, RW ; Davies, MJ ; Crasto, W ; Gray, LJ ; Webb, DR ; Khunti, K</creator><creatorcontrib>Major, RW ; Davies, MJ ; Crasto, W ; Gray, LJ ; Webb, DR ; Khunti, K</creatorcontrib><description>Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in the ADDITION-Leicester study, a UK based multiethnic, community diabetes screening study. Standard definitions included: HTN—mean recorded BP of ⩾140/90 mm Hg, CKD stage 3 and above—estimated glomerular filtration rate (eGFR) <60 ml min
−1
per 1.73 m
2
and microalbuminuria as albumin creatinine ratio ⩾3 mg mmol
−1
. Logistic regression was performed with age, gender and body mass index (kg m
−2
) as co-variates. 6082 individuals (52.5% female, mean age, 57.2 years; White European, 77.8% and South Asian, 22.0%), 31.1% had undiagnosed HTN. Overall, individuals with undiagnosed HTN compared with normotensives had an odds ratio for microalbuminuria of 2.24 (95% confidence interval (CI): 1.72–2.94). For South Asians, the odds ratio was 3.81. (95% CI: 2.24–6.47) for microalbuminuria with a trend towards an eGFR<60 ml min
−1
per 1.73 m
2
. Future studies should consider intensified screening for HTN to refine the population suitable for CKD screening, particularly in the South Asian ethnic group.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2014.62</identifier><identifier>PMID: 25119886</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/1585/104 ; 692/699/75/243 ; 692/700/139 ; Aged ; Albuminuria - complications ; Albuminuria - epidemiology ; Asia, Western - ethnology ; Asian people ; Body mass index ; Creatinine ; Diabetes ; Diabetes mellitus ; Diagnosis ; Epidemiology ; Epidermal growth factor receptors ; Female ; Gender ; Glomerular filtration rate ; Health Administration ; Health risk assessment ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - epidemiology ; Kidney diseases ; Male ; Medicine ; Medicine & Public Health ; Methods ; Middle Aged ; Minority & ethnic groups ; original-article ; Physiological aspects ; Public Health ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - epidemiology</subject><ispartof>Journal of human hypertension, 2015-03, Vol.29 (3), p.185-189</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-922267acc82ab7fe5d6286eafe7f77c75852a40d15ac6e6990a7b4334e86982c3</citedby><cites>FETCH-LOGICAL-c587t-922267acc82ab7fe5d6286eafe7f77c75852a40d15ac6e6990a7b4334e86982c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2014.62$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2014.62$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25119886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Major, RW</creatorcontrib><creatorcontrib>Davies, MJ</creatorcontrib><creatorcontrib>Crasto, W</creatorcontrib><creatorcontrib>Gray, LJ</creatorcontrib><creatorcontrib>Webb, DR</creatorcontrib><creatorcontrib>Khunti, K</creatorcontrib><title>Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in the ADDITION-Leicester study, a UK based multiethnic, community diabetes screening study. Standard definitions included: HTN—mean recorded BP of ⩾140/90 mm Hg, CKD stage 3 and above—estimated glomerular filtration rate (eGFR) <60 ml min
−1
per 1.73 m
2
and microalbuminuria as albumin creatinine ratio ⩾3 mg mmol
−1
. Logistic regression was performed with age, gender and body mass index (kg m
−2
) as co-variates. 6082 individuals (52.5% female, mean age, 57.2 years; White European, 77.8% and South Asian, 22.0%), 31.1% had undiagnosed HTN. Overall, individuals with undiagnosed HTN compared with normotensives had an odds ratio for microalbuminuria of 2.24 (95% confidence interval (CI): 1.72–2.94). For South Asians, the odds ratio was 3.81. (95% CI: 2.24–6.47) for microalbuminuria with a trend towards an eGFR<60 ml min
−1
per 1.73 m
2
. Future studies should consider intensified screening for HTN to refine the population suitable for CKD screening, particularly in the South Asian ethnic group.</description><subject>692/699/1585/104</subject><subject>692/699/75/243</subject><subject>692/700/139</subject><subject>Aged</subject><subject>Albuminuria - complications</subject><subject>Albuminuria - epidemiology</subject><subject>Asia, Western - ethnology</subject><subject>Asian people</subject><subject>Body mass index</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Gender</subject><subject>Glomerular filtration rate</subject><subject>Health Administration</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Public Health</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk2LFDEQhoMo7uzqybsEBBF0xiSdrz4Oi6vCggf1HNLp6umM3cmYdDPsvzfNrLori-QQknryVlXqRegFJRtKKv1-3_cbRijfSPYIrShXci0EU4_RitSCrGvGyRk6z3lPyBLUT9EZE5TWWssV6rc5R-ft5GPADUxHgIDn0Hq7CzFDi_ubA6QJQl4AG1o8epeiHZp59GFO3mIf8Nc4Tz3eZm9Dxkc_9eWMf4R4DLgoFVnIz9CTzg4Znt_uF-j71Ydvl5_W118-fr7cXq-d0Goq1TImlXVOM9uoDkQrmZZgO1CdUk4JLZjlpKXCOgmyrolVDa8qDlrWmrnqAr056R5S_DlDnszos4NhsAHinA2VgitCSpaCvvoH3cc5hVKdYVVFJSWkJv-jilZFGZVE_6V2dgDjQxenZN2S2mw5qTjXmqhCbR6gymqhfGsM0Plyf-_B6zsPerDD1Oc4zMu48n3w7Qksw8k5QWcOyY823RhKzGITU2xiFpsYyQr98ranuRmh_cP-9kUB3p2AXEJhB-lO0w_o_QJmvsSh</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Major, RW</creator><creator>Davies, MJ</creator><creator>Crasto, W</creator><creator>Gray, LJ</creator><creator>Webb, DR</creator><creator>Khunti, K</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes</title><author>Major, RW ; Davies, MJ ; Crasto, W ; Gray, LJ ; Webb, DR ; Khunti, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-922267acc82ab7fe5d6286eafe7f77c75852a40d15ac6e6990a7b4334e86982c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/699/1585/104</topic><topic>692/699/75/243</topic><topic>692/700/139</topic><topic>Aged</topic><topic>Albuminuria - complications</topic><topic>Albuminuria - epidemiology</topic><topic>Asia, Western - ethnology</topic><topic>Asian people</topic><topic>Body mass index</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Gender</topic><topic>Glomerular filtration rate</topic><topic>Health Administration</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Public Health</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Major, RW</creatorcontrib><creatorcontrib>Davies, MJ</creatorcontrib><creatorcontrib>Crasto, W</creatorcontrib><creatorcontrib>Gray, LJ</creatorcontrib><creatorcontrib>Webb, DR</creatorcontrib><creatorcontrib>Khunti, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Major, RW</au><au>Davies, MJ</au><au>Crasto, W</au><au>Gray, LJ</au><au>Webb, DR</au><au>Khunti, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>29</volume><issue>3</issue><spage>185</spage><epage>189</epage><pages>185-189</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in the ADDITION-Leicester study, a UK based multiethnic, community diabetes screening study. Standard definitions included: HTN—mean recorded BP of ⩾140/90 mm Hg, CKD stage 3 and above—estimated glomerular filtration rate (eGFR) <60 ml min
−1
per 1.73 m
2
and microalbuminuria as albumin creatinine ratio ⩾3 mg mmol
−1
. Logistic regression was performed with age, gender and body mass index (kg m
−2
) as co-variates. 6082 individuals (52.5% female, mean age, 57.2 years; White European, 77.8% and South Asian, 22.0%), 31.1% had undiagnosed HTN. Overall, individuals with undiagnosed HTN compared with normotensives had an odds ratio for microalbuminuria of 2.24 (95% confidence interval (CI): 1.72–2.94). For South Asians, the odds ratio was 3.81. (95% CI: 2.24–6.47) for microalbuminuria with a trend towards an eGFR<60 ml min
−1
per 1.73 m
2
. Future studies should consider intensified screening for HTN to refine the population suitable for CKD screening, particularly in the South Asian ethnic group.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25119886</pmid><doi>10.1038/jhh.2014.62</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0950-9240 |
| ispartof | Journal of human hypertension, 2015-03, Vol.29 (3), p.185-189 |
| issn | 0950-9240 1476-5527 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/699/1585/104 692/699/75/243 692/700/139 Aged Albuminuria - complications Albuminuria - epidemiology Asia, Western - ethnology Asian people Body mass index Creatinine Diabetes Diabetes mellitus Diagnosis Epidemiology Epidermal growth factor receptors Female Gender Glomerular filtration rate Health Administration Health risk assessment Humans Hypertension Hypertension - complications Hypertension - epidemiology Kidney diseases Male Medicine Medicine & Public Health Methods Middle Aged Minority & ethnic groups original-article Physiological aspects Public Health Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - epidemiology |
| title | Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes |
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