Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein

Phosphopantetheinyl transferases (PPTases) are key enzymes in the assembly-line production of complex molecules such as fatty acids, polyketides and polypeptides, where they activate acyl or peptidyl carrier proteins, transferring a 4′-phosphopantetheinyl moiety from coenzyme A (CoA) to a reactive s...

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Veröffentlicht in:	Journal of structural biology 2014-12, Vol.188 (3), p.274-278
Hauptverfasser:	Jung, James, Bashiri, Ghader, Johnston, Jodie M., Brown, Alistair S., Ackerley, David F., Baker, Edward N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl carrier protein Amino Acid Sequence Bacterial Proteins - metabolism Crystal structure Crystallography, X-Ray Maltose-Binding Proteins - metabolism MBP fusion protein Mycobacterium tuberculosis Mycobacterium tuberculosis - metabolism Phosphopantetheinyl transferase type-II Protein Structure, Secondary Transferases (Other Substituted Phosphate Groups) - metabolism
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