Pharmacogenetics of Opioid Response

For opioids requiring CYP2D6 O‐demethylation to active metabolites, poor metabolizers have reduced metabolite formation and minimal pain reduction. Clinically, this has only reliably been shown for tramadol. Ultra‐rapid metabolizers have an increased risk of toxicity especially for codeine. ABCB1 ge...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2015-02, Vol.97 (2), p.125-127
Hauptverfasser:	Somogyi, AA, Coller, JK, Barratt, DT
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Cytochrome P-450 Enzyme System - genetics Glucuronosyltransferase - genetics Humans Pain - drug therapy Pain - genetics
Online-Zugang:	Volltext
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