Isolation and characterization of a Pufferfish MLL (Mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax

The MLL gene is interrupted and fused to a number of partner genes as a result of chromosomal translocations in human leukemias. MLL is a very large protein with a unique domain structure and large regions of homology to Drosophila trx. To define the key structural and functional domains of the MLL...

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Veröffentlicht in:	Oncogene 1998-06, Vol.16 (25), p.3233-3241
Hauptverfasser:	CALDAS, C, KIM, M.-H, MACGREGOR, A, CAIN, D, APARICIO, S, WIEDEMANN, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome translocations Comparative analysis Conserved Sequence - genetics Divergence DNA - chemistry DNA - genetics DNA - isolation & purification DNA methyltransferase DNA-Binding Proteins - genetics Drosophila Drosophila - genetics Drosophila Proteins Evolution, Molecular Evolutionary conservation Fishes, Poisonous - genetics Fugu rubripes Fundamental and applied biological sciences. Psychology Genes Genes - genetics Genes, Insect Genome Homology Insects Leukemia Leukemogenesis Marine MLL protein Molecular and cellular biology Molecular Sequence Data Myeloid-Lymphoid Leukemia Protein Nucleotide sequence Proteins Proto-Oncogenes Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Structure-function relationships Transcription Factors
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