Jacalin-carbohydrate interactions: distortion of the ligand molecule as a determinant of affinity

Jacalin is among the most thoroughly studied lectins. Its carbohydrate‐binding site has also been well characterized. It has been postulated that the lower affinity of β‐galactosides for jacalin compared with α‐galactosides is caused by steric interactions of the substituents in the former with the...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2015-02, Vol.71 (2), p.324-331
Hauptverfasser:	Abhinav, K. V., Sharma, Kaushal, Swaminathan, C. P., Surolia, A., Vijayan, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Artocarpus - chemistry Binding Sites Carbohydrates Crystallography, X-Ray galactose-specific lectin Galactosides - chemistry Galactosides - metabolism Ligands Models, Molecular plant lectins Plant Lectins - chemistry Plant Lectins - metabolism post-translational proteolysis Protein Conformation sugar-binding protein T-antigen binding protein β-prism I fold
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