Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities
Summary Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure w...
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| creator | Thomsen, J. S. Jensen, M. V. Niklassen, A. S. Ebbesen, E. N. Brüel, A. |
| description | Summary
Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure was only weakly correlated (
r
= 0.38 to 0.75), despite the overall similar age-related changes.
Introduction
The purposes of the study were to determine the age-related changes in iliac and vertebral bone microstructure for women and men over a large age range and to investigate the relationship between the bone microstructure at these skeletal sites.
Methods
Matched sets of transiliac crest bone biopsies and lumbar vertebral body (L2) specimens from 41 women (19–96 years) and 39 men (23–95 years) were micro-computed tomography (μCT) scanned, and the 3D microstructure was quantified.
Results
For both women and men, bone volume per total volume (BV/TV), connectivity density (CD), and trabecular number (Tb.N) decreased significantly, while structure model index (SMI) and trabecular separation (Tb.Sp) increased significantly with age at either skeletal site. Vertebral trabecular thickness (Tb.Th) was independent of age for both women and men, while iliac Tb.Th decreased significantly with age for men, but not for women. In general, the vertebral and iliac age-related changes were similar. The 95th percentile of the Tb.Th distribution increased significantly with age for women but was independent of age for men at the vertebral body, while it was independent of age for either sex at the iliac crest. The Tb.Th probability density functions at the two skeletal sites became significantly more similar with age for women, but not for men. The microstructural parameters at the iliac crest and the vertebral bodies were only moderately correlated from
r
= 0.38 for SMI in women to
r
= 0.75 for Tb.Sp in men.
Conclusion
Age-related changes in vertebral and iliac bone microstructure were in general similar. The iliac and vertebral Tb.Th distributions became more similar with age for women. Despite the overall similar age-related changes in trabecular bone microstructure, the vertebral and iliac bone microstructural measures were only weakly correlated (
r
= 0.38 to 0.75). |
| doi_str_mv | 10.1007/s00198-014-2851-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1654696909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3549946231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-c2ce5fa3c0e2307c2afd92b4df0c4682b57e2915cde5f048b168093528554f2a3</originalsourceid><addsrcrecordid>eNqFkc1KHjEYhUNpqV9tL8CNBNx0k5pkkslkKWq1ILhpobuQybzRyPxoMiN250X0CnslvsNnSxFKV7PIc07m5CFkT_BPgnNzWDgXtmFcKCYbLdjDK7IRqqqYtLV-TTbcVoZZJb7vkHel3HDMWGvekh2pRa1qazYkHl0By9D7GToarv14BYWmkd5DnqHNvqd-7Gjqkw80ZCgzrU5oO41AhxTyVOa8hHnJ8OvxZ5dihAxjwIY1VNKQep_TnKC8J2-i7wt8eP7ukm-fT78en7OLy7Mvx0cXLCijZxZkAB19FTjIipsgfeysbFUXeVB1I1ttQFqhQ4cYV00r6gZHalyvVZS-2iUft723ebpb8HfdkEqAvvcjTEtxota4u7YY-j-qtGm4ERzRgxfozbTkEYesVIUutBBIiS21vkvJEN1tToPPP5zgbvXltr4c-nKrL_eAmf3n5qUdoPuT-C0IAbkFCh6hnPzX1f9sfQIILKGN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1643100511</pqid></control><display><type>article</type><title>Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Thomsen, J. S. ; Jensen, M. V. ; Niklassen, A. S. ; Ebbesen, E. N. ; Brüel, A.</creator><creatorcontrib>Thomsen, J. S. ; Jensen, M. V. ; Niklassen, A. S. ; Ebbesen, E. N. ; Brüel, A.</creatorcontrib><description>Summary
Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure was only weakly correlated (
r
= 0.38 to 0.75), despite the overall similar age-related changes.
Introduction
The purposes of the study were to determine the age-related changes in iliac and vertebral bone microstructure for women and men over a large age range and to investigate the relationship between the bone microstructure at these skeletal sites.
Methods
Matched sets of transiliac crest bone biopsies and lumbar vertebral body (L2) specimens from 41 women (19–96 years) and 39 men (23–95 years) were micro-computed tomography (μCT) scanned, and the 3D microstructure was quantified.
Results
For both women and men, bone volume per total volume (BV/TV), connectivity density (CD), and trabecular number (Tb.N) decreased significantly, while structure model index (SMI) and trabecular separation (Tb.Sp) increased significantly with age at either skeletal site. Vertebral trabecular thickness (Tb.Th) was independent of age for both women and men, while iliac Tb.Th decreased significantly with age for men, but not for women. In general, the vertebral and iliac age-related changes were similar. The 95th percentile of the Tb.Th distribution increased significantly with age for women but was independent of age for men at the vertebral body, while it was independent of age for either sex at the iliac crest. The Tb.Th probability density functions at the two skeletal sites became significantly more similar with age for women, but not for men. The microstructural parameters at the iliac crest and the vertebral bodies were only moderately correlated from
r
= 0.38 for SMI in women to
r
= 0.75 for Tb.Sp in men.
Conclusion
Age-related changes in vertebral and iliac bone microstructure were in general similar. The iliac and vertebral Tb.Th distributions became more similar with age for women. Despite the overall similar age-related changes in trabecular bone microstructure, the vertebral and iliac bone microstructural measures were only weakly correlated (
r
= 0.38 to 0.75).</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-014-2851-x</identifier><identifier>PMID: 25164697</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Aging - pathology ; Bone diseases ; Endocrinology ; Female ; Humans ; Ilium - diagnostic imaging ; Ilium - ultrastructure ; Imaging, Three-Dimensional - methods ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - ultrastructure ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Orthopedics ; Osteoporosis ; Rheumatology ; Sex Characteristics ; Spine ; Tomography ; X-Ray Microtomography - methods ; Young Adult</subject><ispartof>Osteoporosis international, 2015-01, Vol.26 (1), p.219-228</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-c2ce5fa3c0e2307c2afd92b4df0c4682b57e2915cde5f048b168093528554f2a3</citedby><cites>FETCH-LOGICAL-c475t-c2ce5fa3c0e2307c2afd92b4df0c4682b57e2915cde5f048b168093528554f2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-014-2851-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-014-2851-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25164697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomsen, J. S.</creatorcontrib><creatorcontrib>Jensen, M. V.</creatorcontrib><creatorcontrib>Niklassen, A. S.</creatorcontrib><creatorcontrib>Ebbesen, E. N.</creatorcontrib><creatorcontrib>Brüel, A.</creatorcontrib><title>Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure was only weakly correlated (
r
= 0.38 to 0.75), despite the overall similar age-related changes.
Introduction
The purposes of the study were to determine the age-related changes in iliac and vertebral bone microstructure for women and men over a large age range and to investigate the relationship between the bone microstructure at these skeletal sites.
Methods
Matched sets of transiliac crest bone biopsies and lumbar vertebral body (L2) specimens from 41 women (19–96 years) and 39 men (23–95 years) were micro-computed tomography (μCT) scanned, and the 3D microstructure was quantified.
Results
For both women and men, bone volume per total volume (BV/TV), connectivity density (CD), and trabecular number (Tb.N) decreased significantly, while structure model index (SMI) and trabecular separation (Tb.Sp) increased significantly with age at either skeletal site. Vertebral trabecular thickness (Tb.Th) was independent of age for both women and men, while iliac Tb.Th decreased significantly with age for men, but not for women. In general, the vertebral and iliac age-related changes were similar. The 95th percentile of the Tb.Th distribution increased significantly with age for women but was independent of age for men at the vertebral body, while it was independent of age for either sex at the iliac crest. The Tb.Th probability density functions at the two skeletal sites became significantly more similar with age for women, but not for men. The microstructural parameters at the iliac crest and the vertebral bodies were only moderately correlated from
r
= 0.38 for SMI in women to
r
= 0.75 for Tb.Sp in men.
Conclusion
Age-related changes in vertebral and iliac bone microstructure were in general similar. The iliac and vertebral Tb.Th distributions became more similar with age for women. Despite the overall similar age-related changes in trabecular bone microstructure, the vertebral and iliac bone microstructural measures were only weakly correlated (
r
= 0.38 to 0.75).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Bone diseases</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Ilium - diagnostic imaging</subject><subject>Ilium - ultrastructure</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - ultrastructure</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Rheumatology</subject><subject>Sex Characteristics</subject><subject>Spine</subject><subject>Tomography</subject><subject>X-Ray Microtomography - methods</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1KHjEYhUNpqV9tL8CNBNx0k5pkkslkKWq1ILhpobuQybzRyPxoMiN250X0CnslvsNnSxFKV7PIc07m5CFkT_BPgnNzWDgXtmFcKCYbLdjDK7IRqqqYtLV-TTbcVoZZJb7vkHel3HDMWGvekh2pRa1qazYkHl0By9D7GToarv14BYWmkd5DnqHNvqd-7Gjqkw80ZCgzrU5oO41AhxTyVOa8hHnJ8OvxZ5dihAxjwIY1VNKQep_TnKC8J2-i7wt8eP7ukm-fT78en7OLy7Mvx0cXLCijZxZkAB19FTjIipsgfeysbFUXeVB1I1ttQFqhQ4cYV00r6gZHalyvVZS-2iUft723ebpb8HfdkEqAvvcjTEtxota4u7YY-j-qtGm4ERzRgxfozbTkEYesVIUutBBIiS21vkvJEN1tToPPP5zgbvXltr4c-nKrL_eAmf3n5qUdoPuT-C0IAbkFCh6hnPzX1f9sfQIILKGN</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Thomsen, J. S.</creator><creator>Jensen, M. V.</creator><creator>Niklassen, A. S.</creator><creator>Ebbesen, E. 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N. ; Brüel, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-c2ce5fa3c0e2307c2afd92b4df0c4682b57e2915cde5f048b168093528554f2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Bone diseases</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Ilium - diagnostic imaging</topic><topic>Ilium - ultrastructure</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - ultrastructure</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Rheumatology</topic><topic>Sex Characteristics</topic><topic>Spine</topic><topic>Tomography</topic><topic>X-Ray Microtomography - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomsen, J. S.</creatorcontrib><creatorcontrib>Jensen, M. V.</creatorcontrib><creatorcontrib>Niklassen, A. S.</creatorcontrib><creatorcontrib>Ebbesen, E. N.</creatorcontrib><creatorcontrib>Brüel, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomsen, J. S.</au><au>Jensen, M. V.</au><au>Niklassen, A. S.</au><au>Ebbesen, E. N.</au><au>Brüel, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>26</volume><issue>1</issue><spage>219</spage><epage>228</epage><pages>219-228</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure was only weakly correlated (
r
= 0.38 to 0.75), despite the overall similar age-related changes.
Introduction
The purposes of the study were to determine the age-related changes in iliac and vertebral bone microstructure for women and men over a large age range and to investigate the relationship between the bone microstructure at these skeletal sites.
Methods
Matched sets of transiliac crest bone biopsies and lumbar vertebral body (L2) specimens from 41 women (19–96 years) and 39 men (23–95 years) were micro-computed tomography (μCT) scanned, and the 3D microstructure was quantified.
Results
For both women and men, bone volume per total volume (BV/TV), connectivity density (CD), and trabecular number (Tb.N) decreased significantly, while structure model index (SMI) and trabecular separation (Tb.Sp) increased significantly with age at either skeletal site. Vertebral trabecular thickness (Tb.Th) was independent of age for both women and men, while iliac Tb.Th decreased significantly with age for men, but not for women. In general, the vertebral and iliac age-related changes were similar. The 95th percentile of the Tb.Th distribution increased significantly with age for women but was independent of age for men at the vertebral body, while it was independent of age for either sex at the iliac crest. The Tb.Th probability density functions at the two skeletal sites became significantly more similar with age for women, but not for men. The microstructural parameters at the iliac crest and the vertebral bodies were only moderately correlated from
r
= 0.38 for SMI in women to
r
= 0.75 for Tb.Sp in men.
Conclusion
Age-related changes in vertebral and iliac bone microstructure were in general similar. The iliac and vertebral Tb.Th distributions became more similar with age for women. Despite the overall similar age-related changes in trabecular bone microstructure, the vertebral and iliac bone microstructural measures were only weakly correlated (
r
= 0.38 to 0.75).</abstract><cop>London</cop><pub>Springer London</pub><pmid>25164697</pmid><doi>10.1007/s00198-014-2851-x</doi><tpages>10</tpages></addata></record> |
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| issn | 0937-941X 1433-2965 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Aging Aging - pathology Bone diseases Endocrinology Female Humans Ilium - diagnostic imaging Ilium - ultrastructure Imaging, Three-Dimensional - methods Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - ultrastructure Male Medicine Medicine & Public Health Original Article Orthopedics Osteoporosis Rheumatology Sex Characteristics Spine Tomography X-Ray Microtomography - methods Young Adult |
| title | Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities |
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