Acute stress affects the global DNA methylation profile in rat brain: Modulation by physical exercise

•In this study, acute restraint stress induced a decrease in the global DNA methylation in rat brain.•The adaptive changes on global DNA methylation evoked by acute restraint stress are independent of the expression of the Dnmt1 gene.•Physical exercise modulates the impacts of stress on global DNA m...

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Veröffentlicht in:	Behavioural brain research 2015-02, Vol.279, p.123-128
Hauptverfasser:	Rodrigues, Gelson M., Toffoli, Leandro V., Manfredo, Marcelo H., Francis-Oliveira, José, Silva, Andrey S., Raquel, Hiviny A., Martins-Pinge, Marli C., Moreira, Estefânia G., Fernandes, Karen B., Pelosi, Gislaine G., Gomes, Marcus V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute stress Animals Bdnf Brain - metabolism Brain-Derived Neurotrophic Factor - genetics Cerebral Cortex - metabolism Corticosterone - blood DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation Dnmt1 Epigenesis, Genetic Epigenetics Hippocampus - metabolism Hypothalamus - metabolism Male Periaqueductal Gray - metabolism Physical Conditioning, Animal Physical exercise Rats Rats, Wistar Restraint, Physical Stress, Psychological - genetics Swimming
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