Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia

SCOPE: In this study, the effects of punicalagin on neuroinflammation in LPS‐activated microglia were investigated. METHODS AND RESULTS: The ability of punicalagin to reduce the production of TNF‐α, IL‐6 and prostaglandin E₂ was measured in culture medium using enzyme immunoassay. TNF‐α and IL‐6 gen...

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Veröffentlicht in:	Molecular nutrition & food research 2014-09, Vol.58 (9), p.1843-1851
Hauptverfasser:	Olajide, Olumayokun A, Kumar, Asit, Velagapudi, Ravikanth, Okorji, Uchechukwu P, Fiebich, Bernd L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Cell Survival - drug effects Cells, Cultured culture media Cyclooxygenase 2 - genetics Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - metabolism enzyme immunoassays Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology gene expression Hippocampus - drug effects Hydrolyzable Tannins - pharmacology Inflammation - drug therapy Inflammation - metabolism Interleukin-6 - metabolism Lipopolysaccharides - pharmacology luciferase messenger RNA mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology neurodegenerative diseases neuroglia Neuroinflammation NF-kappa B - metabolism NF-κB Organ Culture Techniques phosphorylation polymerase chain reaction Pomegranate Prostaglandin-E Synthases Prostaglandin-Endoperoxide Synthases - genetics prostaglandins protein synthesis Punicalagin rats Rats, Sprague-Dawley TNF Receptor-Associated Factor 6 - metabolism tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Western blotting
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