Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life
BACKGROUND Radiation treatment volumes in head and neck squamous cell carcinoma (HNSCC) are controversial. The authors report the outcomes, patterns of failure, and quality of life (QOL) of patients who received treatment for HNSCC using intensity‐modulated radiation therapy (IMRT) that eliminated t...
Gespeichert in:
| Veröffentlicht in: | Cancer 2014-12, Vol.120 (24), p.3994-4002 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4002 |
|---|---|
| container_issue | 24 |
| container_start_page | 3994 |
| container_title | Cancer |
| container_volume | 120 |
| creator | Spencer, Christopher R. Gay, Hiram A. Haughey, Bruce H. Nussenbaum, Brian Adkins, Douglas R. Wildes, Tanya M. DeWees, Todd A. Lewis, James S. Thorstad, Wade L. |
| description | BACKGROUND
Radiation treatment volumes in head and neck squamous cell carcinoma (HNSCC) are controversial. The authors report the outcomes, patterns of failure, and quality of life (QOL) of patients who received treatment for HNSCC using intensity‐modulated radiation therapy (IMRT) that eliminated the treatment of contralateral retropharyngeal lymph nodes (RPLNs) in the clinically uninvolved neck.
METHODS
A prospective institutional database was used to identify patients who had primary oral cavity, oropharyngeal, hypopharyngeal, laryngeal, and unknown primary HNSCC for which they received IMRT. There were 3 temporal groups (generations 1‐3). Generation 1 received comprehensive neck IMRT with parotid sparing, generation 2 eliminated the contralateral high level II (HLII) lymph nodes, and generation 3 further eliminated the contralateral RPLNs in the clinically uninvolved neck. Patterns of failure and survival analyses were completed, and QOL data measured using the MD Anderson Dysphagia Inventory were compared in a subset of patients from generations 1 and 3.
RESULTS
In total, 748 patients were identified. Of the 488 patients who received treatment in generation 2 or 3, 406 had a clinically uninvolved contralateral neck. There were no failures in the spared RPLNs (95% confidence interval, 0%‐1.3%) or in the high contralateral neck (95% confidence interval, 0%‐0.7%). QOL data were compared between 44 patients in generation 1 and 51 patients in generation 3. QOL improved both globally and in all domains assessed for generation 3, in which reduced radiotherapy volumes were used (P |
| doi_str_mv | 10.1002/cncr.28938 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1654693929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1654693929</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4988-1a5fc397aa9da0d07592b1ca35d15da1380ef06e0d4b9a1ca33c1c5a7b318df83</originalsourceid><addsrcrecordid>eNp9kc2KFDEUhYMoTs_oxgeQbAQRakwqla5kKc3oNAwKouCuuJ2frmgqqUmqR-qRfEtT3a3uXOXe3C_3HHIQekHJNSWkfquCSte1kEw8QitKZFsR2tSP0YoQIiresG8X6DLn76Vta86eooua04aRRqzQrxvvBhdgcmGPE2gXp94kGGc8RVxKrGKYEniYyq3HyUwpjj2kOexN6SFo3Lt9j715MB5vt9jPw9jjELXJ2AXcG9BHKhj1A-f7AwzxkLEy3mMFSbkQB8Au4wzWHEE3jCk-lNeF9W6acbTYO2ueoScWfDbPz-cV-vr-5svmtrr79GG7eXdXqUYKUVHgVjHZAkgNRJOWy3pHFTCuKddAmSDGkrUhutlJWAZMUcWh3TEqtBXsCr0-7S027g8mT93g8uIXginWO7rmzVoyWcuCvjmhKsWck7HdmNxQPqejpFui6ZZoumM0BX553nvYDUb_Rf9kUYBXZwCyAm8TBOXyP04SXguxqNIT99N5M_9Hstt83Hw-if8GNLWqTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654693929</pqid></control><display><type>article</type><title>Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Spencer, Christopher R. ; Gay, Hiram A. ; Haughey, Bruce H. ; Nussenbaum, Brian ; Adkins, Douglas R. ; Wildes, Tanya M. ; DeWees, Todd A. ; Lewis, James S. ; Thorstad, Wade L.</creator><creatorcontrib>Spencer, Christopher R. ; Gay, Hiram A. ; Haughey, Bruce H. ; Nussenbaum, Brian ; Adkins, Douglas R. ; Wildes, Tanya M. ; DeWees, Todd A. ; Lewis, James S. ; Thorstad, Wade L.</creatorcontrib><description>BACKGROUND
Radiation treatment volumes in head and neck squamous cell carcinoma (HNSCC) are controversial. The authors report the outcomes, patterns of failure, and quality of life (QOL) of patients who received treatment for HNSCC using intensity‐modulated radiation therapy (IMRT) that eliminated the treatment of contralateral retropharyngeal lymph nodes (RPLNs) in the clinically uninvolved neck.
METHODS
A prospective institutional database was used to identify patients who had primary oral cavity, oropharyngeal, hypopharyngeal, laryngeal, and unknown primary HNSCC for which they received IMRT. There were 3 temporal groups (generations 1‐3). Generation 1 received comprehensive neck IMRT with parotid sparing, generation 2 eliminated the contralateral high level II (HLII) lymph nodes, and generation 3 further eliminated the contralateral RPLNs in the clinically uninvolved neck. Patterns of failure and survival analyses were completed, and QOL data measured using the MD Anderson Dysphagia Inventory were compared in a subset of patients from generations 1 and 3.
RESULTS
In total, 748 patients were identified. Of the 488 patients who received treatment in generation 2 or 3, 406 had a clinically uninvolved contralateral neck. There were no failures in the spared RPLNs (95% confidence interval, 0%‐1.3%) or in the high contralateral neck (95% confidence interval, 0%‐0.7%). QOL data were compared between 44 patients in generation 1 and 51 patients in generation 3. QOL improved both globally and in all domains assessed for generation 3, in which reduced radiotherapy volumes were used (P < .007).
CONCLUSIONS
For patients with locally advanced HNSCC, eliminating coverage to the contralateral HLII lymph nodes and contralateral RPLNs in the clinically uninvolved side of the neck is associated with minimal risk of failure in these regions and significantly improved patient‐reported QOL. Cancer 2014;120:3994–4002. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Eliminating radiation therapy to the contralateral retropharyngeal lymph nodes and contralateral high level II lymph nodes in the clinically uninvolved neck does not increase the risk of recurrence in these areas. Limiting radiation treatment volume, as such, translates into improved patient‐reported quality of life.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28938</identifier><identifier>PMID: 25143048</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Female ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - radiotherapy ; head and neck squamous cell carcinoma ; Humans ; intensity‐modulated radiotherapy ; Lymph Nodes - pathology ; Lymph Nodes - radiation effects ; Lymphatic Irradiation - adverse effects ; Lymphatic Irradiation - statistics & numerical data ; Male ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neck ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; patterns of failure ; Pharynx ; Quality of Life ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - adverse effects ; Radiotherapy, Intensity-Modulated - methods ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck ; treatment volumes ; Tumor Burden ; Tumors ; Withholding Treatment ; Young Adult</subject><ispartof>Cancer, 2014-12, Vol.120 (24), p.3994-4002</ispartof><rights>2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4988-1a5fc397aa9da0d07592b1ca35d15da1380ef06e0d4b9a1ca33c1c5a7b318df83</citedby><cites>FETCH-LOGICAL-c4988-1a5fc397aa9da0d07592b1ca35d15da1380ef06e0d4b9a1ca33c1c5a7b318df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28938$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28938$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29052889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25143048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spencer, Christopher R.</creatorcontrib><creatorcontrib>Gay, Hiram A.</creatorcontrib><creatorcontrib>Haughey, Bruce H.</creatorcontrib><creatorcontrib>Nussenbaum, Brian</creatorcontrib><creatorcontrib>Adkins, Douglas R.</creatorcontrib><creatorcontrib>Wildes, Tanya M.</creatorcontrib><creatorcontrib>DeWees, Todd A.</creatorcontrib><creatorcontrib>Lewis, James S.</creatorcontrib><creatorcontrib>Thorstad, Wade L.</creatorcontrib><title>Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Radiation treatment volumes in head and neck squamous cell carcinoma (HNSCC) are controversial. The authors report the outcomes, patterns of failure, and quality of life (QOL) of patients who received treatment for HNSCC using intensity‐modulated radiation therapy (IMRT) that eliminated the treatment of contralateral retropharyngeal lymph nodes (RPLNs) in the clinically uninvolved neck.
METHODS
A prospective institutional database was used to identify patients who had primary oral cavity, oropharyngeal, hypopharyngeal, laryngeal, and unknown primary HNSCC for which they received IMRT. There were 3 temporal groups (generations 1‐3). Generation 1 received comprehensive neck IMRT with parotid sparing, generation 2 eliminated the contralateral high level II (HLII) lymph nodes, and generation 3 further eliminated the contralateral RPLNs in the clinically uninvolved neck. Patterns of failure and survival analyses were completed, and QOL data measured using the MD Anderson Dysphagia Inventory were compared in a subset of patients from generations 1 and 3.
RESULTS
In total, 748 patients were identified. Of the 488 patients who received treatment in generation 2 or 3, 406 had a clinically uninvolved contralateral neck. There were no failures in the spared RPLNs (95% confidence interval, 0%‐1.3%) or in the high contralateral neck (95% confidence interval, 0%‐0.7%). QOL data were compared between 44 patients in generation 1 and 51 patients in generation 3. QOL improved both globally and in all domains assessed for generation 3, in which reduced radiotherapy volumes were used (P < .007).
CONCLUSIONS
For patients with locally advanced HNSCC, eliminating coverage to the contralateral HLII lymph nodes and contralateral RPLNs in the clinically uninvolved side of the neck is associated with minimal risk of failure in these regions and significantly improved patient‐reported QOL. Cancer 2014;120:3994–4002. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Eliminating radiation therapy to the contralateral retropharyngeal lymph nodes and contralateral high level II lymph nodes in the clinically uninvolved neck does not increase the risk of recurrence in these areas. Limiting radiation treatment volume, as such, translates into improved patient‐reported quality of life.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Female</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>head and neck squamous cell carcinoma</subject><subject>Humans</subject><subject>intensity‐modulated radiotherapy</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - radiation effects</subject><subject>Lymphatic Irradiation - adverse effects</subject><subject>Lymphatic Irradiation - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neck</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>patterns of failure</subject><subject>Pharynx</subject><subject>Quality of Life</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - adverse effects</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Retrospective Studies</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>treatment volumes</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Withholding Treatment</subject><subject>Young Adult</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoTs_oxgeQbAQRakwqla5kKc3oNAwKouCuuJ2frmgqqUmqR-qRfEtT3a3uXOXe3C_3HHIQekHJNSWkfquCSte1kEw8QitKZFsR2tSP0YoQIiresG8X6DLn76Vta86eooua04aRRqzQrxvvBhdgcmGPE2gXp94kGGc8RVxKrGKYEniYyq3HyUwpjj2kOexN6SFo3Lt9j715MB5vt9jPw9jjELXJ2AXcG9BHKhj1A-f7AwzxkLEy3mMFSbkQB8Au4wzWHEE3jCk-lNeF9W6acbTYO2ueoScWfDbPz-cV-vr-5svmtrr79GG7eXdXqUYKUVHgVjHZAkgNRJOWy3pHFTCuKddAmSDGkrUhutlJWAZMUcWh3TEqtBXsCr0-7S027g8mT93g8uIXginWO7rmzVoyWcuCvjmhKsWck7HdmNxQPqejpFui6ZZoumM0BX553nvYDUb_Rf9kUYBXZwCyAm8TBOXyP04SXguxqNIT99N5M_9Hstt83Hw-if8GNLWqTg</recordid><startdate>20141215</startdate><enddate>20141215</enddate><creator>Spencer, Christopher R.</creator><creator>Gay, Hiram A.</creator><creator>Haughey, Bruce H.</creator><creator>Nussenbaum, Brian</creator><creator>Adkins, Douglas R.</creator><creator>Wildes, Tanya M.</creator><creator>DeWees, Todd A.</creator><creator>Lewis, James S.</creator><creator>Thorstad, Wade L.</creator><general>Wiley-Blackwell</general><scope>24P</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20141215</creationdate><title>Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life</title><author>Spencer, Christopher R. ; Gay, Hiram A. ; Haughey, Bruce H. ; Nussenbaum, Brian ; Adkins, Douglas R. ; Wildes, Tanya M. ; DeWees, Todd A. ; Lewis, James S. ; Thorstad, Wade L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4988-1a5fc397aa9da0d07592b1ca35d15da1380ef06e0d4b9a1ca33c1c5a7b318df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Female</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>head and neck squamous cell carcinoma</topic><topic>Humans</topic><topic>intensity‐modulated radiotherapy</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - radiation effects</topic><topic>Lymphatic Irradiation - adverse effects</topic><topic>Lymphatic Irradiation - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neck</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>patterns of failure</topic><topic>Pharynx</topic><topic>Quality of Life</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - adverse effects</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Retrospective Studies</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>treatment volumes</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Withholding Treatment</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spencer, Christopher R.</creatorcontrib><creatorcontrib>Gay, Hiram A.</creatorcontrib><creatorcontrib>Haughey, Bruce H.</creatorcontrib><creatorcontrib>Nussenbaum, Brian</creatorcontrib><creatorcontrib>Adkins, Douglas R.</creatorcontrib><creatorcontrib>Wildes, Tanya M.</creatorcontrib><creatorcontrib>DeWees, Todd A.</creatorcontrib><creatorcontrib>Lewis, James S.</creatorcontrib><creatorcontrib>Thorstad, Wade L.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spencer, Christopher R.</au><au>Gay, Hiram A.</au><au>Haughey, Bruce H.</au><au>Nussenbaum, Brian</au><au>Adkins, Douglas R.</au><au>Wildes, Tanya M.</au><au>DeWees, Todd A.</au><au>Lewis, James S.</au><au>Thorstad, Wade L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-12-15</date><risdate>2014</risdate><volume>120</volume><issue>24</issue><spage>3994</spage><epage>4002</epage><pages>3994-4002</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Radiation treatment volumes in head and neck squamous cell carcinoma (HNSCC) are controversial. The authors report the outcomes, patterns of failure, and quality of life (QOL) of patients who received treatment for HNSCC using intensity‐modulated radiation therapy (IMRT) that eliminated the treatment of contralateral retropharyngeal lymph nodes (RPLNs) in the clinically uninvolved neck.
METHODS
A prospective institutional database was used to identify patients who had primary oral cavity, oropharyngeal, hypopharyngeal, laryngeal, and unknown primary HNSCC for which they received IMRT. There were 3 temporal groups (generations 1‐3). Generation 1 received comprehensive neck IMRT with parotid sparing, generation 2 eliminated the contralateral high level II (HLII) lymph nodes, and generation 3 further eliminated the contralateral RPLNs in the clinically uninvolved neck. Patterns of failure and survival analyses were completed, and QOL data measured using the MD Anderson Dysphagia Inventory were compared in a subset of patients from generations 1 and 3.
RESULTS
In total, 748 patients were identified. Of the 488 patients who received treatment in generation 2 or 3, 406 had a clinically uninvolved contralateral neck. There were no failures in the spared RPLNs (95% confidence interval, 0%‐1.3%) or in the high contralateral neck (95% confidence interval, 0%‐0.7%). QOL data were compared between 44 patients in generation 1 and 51 patients in generation 3. QOL improved both globally and in all domains assessed for generation 3, in which reduced radiotherapy volumes were used (P < .007).
CONCLUSIONS
For patients with locally advanced HNSCC, eliminating coverage to the contralateral HLII lymph nodes and contralateral RPLNs in the clinically uninvolved side of the neck is associated with minimal risk of failure in these regions and significantly improved patient‐reported QOL. Cancer 2014;120:3994–4002. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Eliminating radiation therapy to the contralateral retropharyngeal lymph nodes and contralateral high level II lymph nodes in the clinically uninvolved neck does not increase the risk of recurrence in these areas. Limiting radiation treatment volume, as such, translates into improved patient‐reported quality of life.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>25143048</pmid><doi>10.1002/cncr.28938</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 2014-12, Vol.120 (24), p.3994-4002 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1654693929 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Female Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy head and neck squamous cell carcinoma Humans intensity‐modulated radiotherapy Lymph Nodes - pathology Lymph Nodes - radiation effects Lymphatic Irradiation - adverse effects Lymphatic Irradiation - statistics & numerical data Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neck Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology patterns of failure Pharynx Quality of Life Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - adverse effects Radiotherapy, Intensity-Modulated - methods Retrospective Studies Squamous Cell Carcinoma of Head and Neck treatment volumes Tumor Burden Tumors Withholding Treatment Young Adult |
| title | Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T23%3A03%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Eliminating%20radiotherapy%20to%20the%20contralateral%20retropharyngeal%20and%20high%20level%20II%20lymph%20nodes%20in%20head%20and%20neck%20squamous%20cell%20carcinoma%20is%20safe%20and%20improves%20quality%20of%20life&rft.jtitle=Cancer&rft.au=Spencer,%20Christopher%20R.&rft.date=2014-12-15&rft.volume=120&rft.issue=24&rft.spage=3994&rft.epage=4002&rft.pages=3994-4002&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/cncr.28938&rft_dat=%3Cproquest_cross%3E1654693929%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1654693929&rft_id=info:pmid/25143048&rfr_iscdi=true |