Association of variants in genes related to the immune response and obesity with BPH in CLUE II
Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single...
Gespeichert in:
| Veröffentlicht in: | Prostate cancer and prostatic diseases 2014-12, Vol.17 (4), p.353-358 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 358 |
|---|---|
| container_issue | 4 |
| container_start_page | 353 |
| container_title | Prostate cancer and prostatic diseases |
| container_volume | 17 |
| creator | Lopez, D S Peskoe, S B Tsilidis, K K Hoffman-Bolton, J Helzlsouer, K J Isaacs, W B Smith, M W Platz, E A |
| description | Background:
Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (
IL1B, IL6, IL8, IL10, TNF, CRP, TLR4
and
RNASEL
) and genes involved in obesity, including insulin regulation (
LEP, ADIPOQ, PPARG
and
TCF7L2
), with BPH.
Methods:
BPH cases (
N
=568) and age-frequency matched controls (
N
=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ⩾15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ⩽7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
Results:
None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for
CRP
rs1205 (1082C>T),
ADIPOQ
rs1501299 (276C>A),
PPARG
rs1801282 (-49C>G) and
TCF7L2
rs7903146 (47833T>C). After summing risk alleles, men with ⩾4 had an increased BPH risk compared with those with ⩽1 (OR, 1.78; 95% CI, 1.10–2.89;
P
trend
=0.006).
Conclusions:
SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH. |
| doi_str_mv | 10.1038/pcan.2014.36 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1654691748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A390871019</galeid><sourcerecordid>A390871019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c624t-49b7eadc43127235bf51abfdfc2db3f8a128aeddea5fe11c3ab4b376c9684c8d3</originalsourceid><addsrcrecordid>eNqNks9rFDEcxQdRbK3ePEtAEA_Omt-TOa5LtQsFPdhzyGS-2U2ZSdZJRul_b4at2koRySHhm8974ZFXVS8JXhHM1PuDNWFFMeErJh9Vp4Q3shYSq8flzKSoGyXoSfUspWuMcUta_LQ6oYJSLoQ6rfQ6pWi9yT4GFB36biZvQk7IB7SDAAlNMJgMPcoR5T0gP45zgDJNhxgSIBN6FDtIPt-gHz7v0YcvF4t4c3l1jrbb59UTZ4YEL273s-rq4_nXzUV9-fnTdrO-rK2kPNe87RowveWM0IYy0TlBTOd6Z2nfMacMocpA34MRDgixzHS8Y420rVTcqp6dVW-PvocpfpshZT36ZGEYTIA4J02k4LIlDVf_gVIqii8VBX39F3od5ymUIJpKLhilpGn_RS1euClu9A-1MwNoH1zMk7HL03rNWqwagsnitXqAKquH0dsYwPkyvyd4c0ewBzPkfYrDvHxoug--O4J2iilN4PRh8qOZbjTBemmSXpqklyZpJgv-6jbU3I3Q_4Z_VacA9RFI5SrsYLqT-iHDn-XFzvw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1622075962</pqid></control><display><type>article</type><title>Association of variants in genes related to the immune response and obesity with BPH in CLUE II</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lopez, D S ; Peskoe, S B ; Tsilidis, K K ; Hoffman-Bolton, J ; Helzlsouer, K J ; Isaacs, W B ; Smith, M W ; Platz, E A</creator><creatorcontrib>Lopez, D S ; Peskoe, S B ; Tsilidis, K K ; Hoffman-Bolton, J ; Helzlsouer, K J ; Isaacs, W B ; Smith, M W ; Platz, E A</creatorcontrib><description>Background:
Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (
IL1B, IL6, IL8, IL10, TNF, CRP, TLR4
and
RNASEL
) and genes involved in obesity, including insulin regulation (
LEP, ADIPOQ, PPARG
and
TCF7L2
), with BPH.
Methods:
BPH cases (
N
=568) and age-frequency matched controls (
N
=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ⩾15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ⩽7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
Results:
None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for
CRP
rs1205 (1082C>T),
ADIPOQ
rs1501299 (276C>A),
PPARG
rs1801282 (-49C>G) and
TCF7L2
rs7903146 (47833T>C). After summing risk alleles, men with ⩾4 had an increased BPH risk compared with those with ⩽1 (OR, 1.78; 95% CI, 1.10–2.89;
P
trend
=0.006).
Conclusions:
SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.</description><identifier>ISSN: 1365-7852</identifier><identifier>ISSN: 1476-5608</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/pcan.2014.36</identifier><identifier>PMID: 25224558</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/2768/1753 ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Confidence intervals ; Genes ; Genetic aspects ; Genotype ; Humans ; Hypertrophy ; Identification and classification ; IL-1β ; Immune response ; Immune system ; Immunity - genetics ; Insulin ; Interleukin 1 ; Interleukin 10 ; Interleukin 6 ; Interleukin 8 ; Male ; Middle Aged ; Nucleotides ; Obesity ; Obesity - complications ; Obesity - genetics ; Obesity - immunology ; Odds Ratio ; original-article ; Peroxisome proliferator-activated receptors ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Prostate ; Prostatic Hyperplasia - complications ; Prostatic Hyperplasia - genetics ; Prostatic Hyperplasia - immunology ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Statistical analysis ; Surgery ; TLR4 protein ; Toll-like receptors ; Tumor necrosis factor ; Urinary tract</subject><ispartof>Prostate cancer and prostatic diseases, 2014-12, Vol.17 (4), p.353-358</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2014</rights><rights>Macmillan Publishers Limited 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-49b7eadc43127235bf51abfdfc2db3f8a128aeddea5fe11c3ab4b376c9684c8d3</citedby><cites>FETCH-LOGICAL-c624t-49b7eadc43127235bf51abfdfc2db3f8a128aeddea5fe11c3ab4b376c9684c8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25224558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez, D S</creatorcontrib><creatorcontrib>Peskoe, S B</creatorcontrib><creatorcontrib>Tsilidis, K K</creatorcontrib><creatorcontrib>Hoffman-Bolton, J</creatorcontrib><creatorcontrib>Helzlsouer, K J</creatorcontrib><creatorcontrib>Isaacs, W B</creatorcontrib><creatorcontrib>Smith, M W</creatorcontrib><creatorcontrib>Platz, E A</creatorcontrib><title>Association of variants in genes related to the immune response and obesity with BPH in CLUE II</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><description>Background:
Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (
IL1B, IL6, IL8, IL10, TNF, CRP, TLR4
and
RNASEL
) and genes involved in obesity, including insulin regulation (
LEP, ADIPOQ, PPARG
and
TCF7L2
), with BPH.
Methods:
BPH cases (
N
=568) and age-frequency matched controls (
N
=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ⩾15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ⩽7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
Results:
None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for
CRP
rs1205 (1082C>T),
ADIPOQ
rs1501299 (276C>A),
PPARG
rs1801282 (-49C>G) and
TCF7L2
rs7903146 (47833T>C). After summing risk alleles, men with ⩾4 had an increased BPH risk compared with those with ⩽1 (OR, 1.78; 95% CI, 1.10–2.89;
P
trend
=0.006).
Conclusions:
SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.</description><subject>692/699/2768/1753</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Confidence intervals</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Identification and classification</subject><subject>IL-1β</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity - genetics</subject><subject>Insulin</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nucleotides</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Obesity - immunology</subject><subject>Odds Ratio</subject><subject>original-article</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate</subject><subject>Prostatic Hyperplasia - complications</subject><subject>Prostatic Hyperplasia - genetics</subject><subject>Prostatic Hyperplasia - immunology</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Tumor necrosis factor</subject><subject>Urinary tract</subject><issn>1365-7852</issn><issn>1476-5608</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks9rFDEcxQdRbK3ePEtAEA_Omt-TOa5LtQsFPdhzyGS-2U2ZSdZJRul_b4at2koRySHhm8974ZFXVS8JXhHM1PuDNWFFMeErJh9Vp4Q3shYSq8flzKSoGyXoSfUspWuMcUta_LQ6oYJSLoQ6rfQ6pWi9yT4GFB36biZvQk7IB7SDAAlNMJgMPcoR5T0gP45zgDJNhxgSIBN6FDtIPt-gHz7v0YcvF4t4c3l1jrbb59UTZ4YEL273s-rq4_nXzUV9-fnTdrO-rK2kPNe87RowveWM0IYy0TlBTOd6Z2nfMacMocpA34MRDgixzHS8Y420rVTcqp6dVW-PvocpfpshZT36ZGEYTIA4J02k4LIlDVf_gVIqii8VBX39F3od5ymUIJpKLhilpGn_RS1euClu9A-1MwNoH1zMk7HL03rNWqwagsnitXqAKquH0dsYwPkyvyd4c0ewBzPkfYrDvHxoug--O4J2iilN4PRh8qOZbjTBemmSXpqklyZpJgv-6jbU3I3Q_4Z_VacA9RFI5SrsYLqT-iHDn-XFzvw</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Lopez, D S</creator><creator>Peskoe, S B</creator><creator>Tsilidis, K K</creator><creator>Hoffman-Bolton, J</creator><creator>Helzlsouer, K J</creator><creator>Isaacs, W B</creator><creator>Smith, M W</creator><creator>Platz, E A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7T5</scope></search><sort><creationdate>20141201</creationdate><title>Association of variants in genes related to the immune response and obesity with BPH in CLUE II</title><author>Lopez, D S ; Peskoe, S B ; Tsilidis, K K ; Hoffman-Bolton, J ; Helzlsouer, K J ; Isaacs, W B ; Smith, M W ; Platz, E A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-49b7eadc43127235bf51abfdfc2db3f8a128aeddea5fe11c3ab4b376c9684c8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/2768/1753</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Confidence intervals</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Identification and classification</topic><topic>IL-1β</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity - genetics</topic><topic>Insulin</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nucleotides</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Obesity - immunology</topic><topic>Odds Ratio</topic><topic>original-article</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate</topic><topic>Prostatic Hyperplasia - complications</topic><topic>Prostatic Hyperplasia - genetics</topic><topic>Prostatic Hyperplasia - immunology</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor</topic><topic>Urinary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez, D S</creatorcontrib><creatorcontrib>Peskoe, S B</creatorcontrib><creatorcontrib>Tsilidis, K K</creatorcontrib><creatorcontrib>Hoffman-Bolton, J</creatorcontrib><creatorcontrib>Helzlsouer, K J</creatorcontrib><creatorcontrib>Isaacs, W B</creatorcontrib><creatorcontrib>Smith, M W</creatorcontrib><creatorcontrib>Platz, E A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez, D S</au><au>Peskoe, S B</au><au>Tsilidis, K K</au><au>Hoffman-Bolton, J</au><au>Helzlsouer, K J</au><au>Isaacs, W B</au><au>Smith, M W</au><au>Platz, E A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of variants in genes related to the immune response and obesity with BPH in CLUE II</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>17</volume><issue>4</issue><spage>353</spage><epage>358</epage><pages>353-358</pages><issn>1365-7852</issn><issn>1476-5608</issn><eissn>1476-5608</eissn><abstract>Background:
Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (
IL1B, IL6, IL8, IL10, TNF, CRP, TLR4
and
RNASEL
) and genes involved in obesity, including insulin regulation (
LEP, ADIPOQ, PPARG
and
TCF7L2
), with BPH.
Methods:
BPH cases (
N
=568) and age-frequency matched controls (
N
=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ⩾15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ⩽7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
Results:
None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for
CRP
rs1205 (1082C>T),
ADIPOQ
rs1501299 (276C>A),
PPARG
rs1801282 (-49C>G) and
TCF7L2
rs7903146 (47833T>C). After summing risk alleles, men with ⩾4 had an increased BPH risk compared with those with ⩽1 (OR, 1.78; 95% CI, 1.10–2.89;
P
trend
=0.006).
Conclusions:
SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25224558</pmid><doi>10.1038/pcan.2014.36</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1365-7852 |
| ispartof | Prostate cancer and prostatic diseases, 2014-12, Vol.17 (4), p.353-358 |
| issn | 1365-7852 1476-5608 1476-5608 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1654691748 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 692/699/2768/1753 Aged Biomedical and Life Sciences Biomedicine Cancer Research Confidence intervals Genes Genetic aspects Genotype Humans Hypertrophy Identification and classification IL-1β Immune response Immune system Immunity - genetics Insulin Interleukin 1 Interleukin 10 Interleukin 6 Interleukin 8 Male Middle Aged Nucleotides Obesity Obesity - complications Obesity - genetics Obesity - immunology Odds Ratio original-article Peroxisome proliferator-activated receptors Polymerase Chain Reaction Polymorphism, Single Nucleotide Prostate Prostatic Hyperplasia - complications Prostatic Hyperplasia - genetics Prostatic Hyperplasia - immunology Single nucleotide polymorphisms Single-nucleotide polymorphism Statistical analysis Surgery TLR4 protein Toll-like receptors Tumor necrosis factor Urinary tract |
| title | Association of variants in genes related to the immune response and obesity with BPH in CLUE II |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T03%3A18%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20variants%20in%20genes%20related%20to%20the%20immune%20response%20and%20obesity%20with%20BPH%20in%20CLUE%20II&rft.jtitle=Prostate%20cancer%20and%20prostatic%20diseases&rft.au=Lopez,%20D%20S&rft.date=2014-12-01&rft.volume=17&rft.issue=4&rft.spage=353&rft.epage=358&rft.pages=353-358&rft.issn=1365-7852&rft.eissn=1476-5608&rft_id=info:doi/10.1038/pcan.2014.36&rft_dat=%3Cgale_proqu%3EA390871019%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1622075962&rft_id=info:pmid/25224558&rft_galeid=A390871019&rfr_iscdi=true |