Association of variants in genes related to the immune response and obesity with BPH in CLUE II
Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single...
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Veröffentlicht in: | Prostate cancer and prostatic diseases 2014-12, Vol.17 (4), p.353-358 |
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Zusammenfassung: | Background:
Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (
IL1B, IL6, IL8, IL10, TNF, CRP, TLR4
and
RNASEL
) and genes involved in obesity, including insulin regulation (
LEP, ADIPOQ, PPARG
and
TCF7L2
), with BPH.
Methods:
BPH cases (
N
=568) and age-frequency matched controls (
N
=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ⩾15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ⩽7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
Results:
None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for
CRP
rs1205 (1082C>T),
ADIPOQ
rs1501299 (276C>A),
PPARG
rs1801282 (-49C>G) and
TCF7L2
rs7903146 (47833T>C). After summing risk alleles, men with ⩾4 had an increased BPH risk compared with those with ⩽1 (OR, 1.78; 95% CI, 1.10–2.89;
P
trend
=0.006).
Conclusions:
SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH. |
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ISSN: | 1365-7852 1476-5608 1476-5608 |
DOI: | 10.1038/pcan.2014.36 |