Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis
Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration‐based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et ...
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| Veröffentlicht in: | European journal of immunology 2015-01, Vol.45 (1), p.40-43 |
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| container_title | European journal of immunology |
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| creator | Sozzani, Silvano Del Prete, Annalisa |
| description | Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration‐based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et al. [Eur. J. Immunol. 2015. 45: 101–112] show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte‐derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1α for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration. |
| doi_str_mv | 10.1002/eji.201445305 |
| format | Article |
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| subjects | Chemokine CCL3 - immunology Chemokines Chemotaxis Dendritic cells Dendritic Cells - drug effects Humans Interleukin-8 - immunology Migration Monocytes Monocytes - drug effects Serum amyloid A Serum Amyloid A Protein - pharmacology |
| title | Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis |
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