Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer
s In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPAR is a newly detected lncRNA; in previous study, we found out that ncRuPAR could inhibit tumor progression by downregulating protease-activated receptor-1 (PAR-1), but its role in colorectal cancer...
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| Veröffentlicht in: | Tumor biology 2014-11, Vol.35 (11), p.11329-11335 |
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| creator | Yan, Bing Gu, Wei Yang, Zhihui Gu, Zhan Yue, Xiaoqiang Gu, Qunhao Liu, Long |
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In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPAR is a newly detected lncRNA; in previous study, we found out that ncRuPAR could inhibit tumor progression by downregulating protease-activated receptor-1 (PAR-1), but its role in colorectal cancer (CRC) is never elucidated. Here, we conducted a self-control study which includes 105 CRC samples. By quantitative real time PCR (qRT-PCR) and immunohistochemical staining, we detected the expression of ncRuPAR and PAR-1 as well as their correlation; we further associated these data with the clinicopathologic parameters. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of ncRuPAR and PAR-1, respectively. Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck’s stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. The area under the ROC curve of ncRuPAR was 0.81 (95 % confidence interval (CI): 0.75–0.87); at a cutoff value of 8.34, the ncRuPAR measurement had a sensitivity of 97.14 %, a specificity of 65.87 %, and an accuracy of 82.86 % to predict CRC. |
| doi_str_mv | 10.1007/s13277-014-2465-0 |
| format | Article |
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In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPAR is a newly detected lncRNA; in previous study, we found out that ncRuPAR could inhibit tumor progression by downregulating protease-activated receptor-1 (PAR-1), but its role in colorectal cancer (CRC) is never elucidated. Here, we conducted a self-control study which includes 105 CRC samples. By quantitative real time PCR (qRT-PCR) and immunohistochemical staining, we detected the expression of ncRuPAR and PAR-1 as well as their correlation; we further associated these data with the clinicopathologic parameters. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of ncRuPAR and PAR-1, respectively. Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck’s stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. The area under the ROC curve of ncRuPAR was 0.81 (95 % confidence interval (CI): 0.75–0.87); at a cutoff value of 8.34, the ncRuPAR measurement had a sensitivity of 97.14 %, a specificity of 65.87 %, and an accuracy of 82.86 % to predict CRC.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-014-2465-0</identifier><identifier>PMID: 25119598</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; Cellular biology ; Colon - metabolism ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Down-Regulation ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Male ; Metastasis ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Protein expression ; Real-Time Polymerase Chain Reaction ; Receptor, PAR-1 - antagonists & inhibitors ; Receptor, PAR-1 - genetics ; Receptor, PAR-1 - metabolism ; Rectum - metabolism ; Research Article ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; ROC Curve ; Survival Rate</subject><ispartof>Tumor biology, 2014-11, Vol.35 (11), p.11329-11335</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-81d20b4e5044733afdb65b58782555b9620b5a53f84744aab915d6171ebed88d3</citedby><cites>FETCH-LOGICAL-c475t-81d20b4e5044733afdb65b58782555b9620b5a53f84744aab915d6171ebed88d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-014-2465-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-014-2465-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25119598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Bing</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Yang, Zhihui</creatorcontrib><creatorcontrib>Gu, Zhan</creatorcontrib><creatorcontrib>Yue, Xiaoqiang</creatorcontrib><creatorcontrib>Gu, Qunhao</creatorcontrib><creatorcontrib>Liu, Long</creatorcontrib><title>Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>s
In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPAR is a newly detected lncRNA; in previous study, we found out that ncRuPAR could inhibit tumor progression by downregulating protease-activated receptor-1 (PAR-1), but its role in colorectal cancer (CRC) is never elucidated. Here, we conducted a self-control study which includes 105 CRC samples. By quantitative real time PCR (qRT-PCR) and immunohistochemical staining, we detected the expression of ncRuPAR and PAR-1 as well as their correlation; we further associated these data with the clinicopathologic parameters. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of ncRuPAR and PAR-1, respectively. Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck’s stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. The area under the ROC curve of ncRuPAR was 0.81 (95 % confidence interval (CI): 0.75–0.87); at a cutoff value of 8.34, the ncRuPAR measurement had a sensitivity of 97.14 %, a specificity of 65.87 %, and an accuracy of 82.86 % to predict CRC.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Cellular biology</subject><subject>Colon - metabolism</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Protein expression</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptor, PAR-1 - antagonists & inhibitors</subject><subject>Receptor, PAR-1 - genetics</subject><subject>Receptor, PAR-1 - metabolism</subject><subject>Rectum - metabolism</subject><subject>Research Article</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>ROC Curve</subject><subject>Survival Rate</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkV9rHSEQxaU0JGnSD9CXIvSlLyaOq6s-XtJ_gZCWS_os6rq3hr2a6i4h377e3qSUQiFPMzC_c4aZg9AboGdAqTyv0DEpCQVOGO8FoS_QMXDWEdop-rL1FCjhTHVH6FWtt5SC0Lo_REdMAGih1THyH_J9KmGzTHaOOeE8YounnDY45eTzEFu3vl6R5NfLt9Ua-5zmEt0yh4rnjOdlmwuO6Ud08bc-poZMuQQ_2wl7m3wop-hgtFMNrx_rCfr-6ePNxRdy9fXz5cXqinguxUwUDIw6HgTlXHadHQfXCyeUVEwI4XTfpsKKblRccm6t0yCGHiQEFwalhu4Evd_73pX8cwl1NttYfZgmm0JeqoFe8F4DleIZKFOCKc6goe_-QW_zUlI7ZEdJ3b6vdxTsKV9yrSWM5q7ErS0PBqjZhWX2YZmGm11YhjbN20fnxW3D8EfxlE4D2B6obZQ2ofy1-r-uvwBA3J27</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Yan, Bing</creator><creator>Gu, Wei</creator><creator>Yang, Zhihui</creator><creator>Gu, Zhan</creator><creator>Yue, Xiaoqiang</creator><creator>Gu, Qunhao</creator><creator>Liu, Long</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20141101</creationdate><title>Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer</title><author>Yan, Bing ; Gu, Wei ; Yang, Zhihui ; Gu, Zhan ; Yue, Xiaoqiang ; Gu, Qunhao ; Liu, Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-81d20b4e5044733afdb65b58782555b9620b5a53f84744aab915d6171ebed88d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Cellular biology</topic><topic>Colon - metabolism</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Protein expression</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptor, PAR-1 - antagonists & inhibitors</topic><topic>Receptor, PAR-1 - genetics</topic><topic>Receptor, PAR-1 - metabolism</topic><topic>Rectum - metabolism</topic><topic>Research Article</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - 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Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Bing</au><au>Gu, Wei</au><au>Yang, Zhihui</au><au>Gu, Zhan</au><au>Yue, Xiaoqiang</au><au>Gu, Qunhao</au><au>Liu, Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>35</volume><issue>11</issue><spage>11329</spage><epage>11335</epage><pages>11329-11335</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>s
In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPAR is a newly detected lncRNA; in previous study, we found out that ncRuPAR could inhibit tumor progression by downregulating protease-activated receptor-1 (PAR-1), but its role in colorectal cancer (CRC) is never elucidated. Here, we conducted a self-control study which includes 105 CRC samples. By quantitative real time PCR (qRT-PCR) and immunohistochemical staining, we detected the expression of ncRuPAR and PAR-1 as well as their correlation; we further associated these data with the clinicopathologic parameters. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of ncRuPAR and PAR-1, respectively. Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck’s stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. The area under the ROC curve of ncRuPAR was 0.81 (95 % confidence interval (CI): 0.75–0.87); at a cutoff value of 8.34, the ncRuPAR measurement had a sensitivity of 97.14 %, a specificity of 65.87 %, and an accuracy of 82.86 % to predict CRC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>25119598</pmid><doi>10.1007/s13277-014-2465-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Cellular biology Colon - metabolism Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Down-Regulation Female Follow-Up Studies Humans Lymphatic Metastasis Male Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Protein expression Real-Time Polymerase Chain Reaction Receptor, PAR-1 - antagonists & inhibitors Receptor, PAR-1 - genetics Receptor, PAR-1 - metabolism Rectum - metabolism Research Article Ribonucleic acid RNA RNA, Long Noncoding - genetics ROC Curve Survival Rate |
| title | Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer |
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