Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia?
Background Severe hypogammaglobulinemia (IgG
Gespeichert in:
| Veröffentlicht in: | Clinical transplantation 2014-11, Vol.28 (11), p.1249-1255 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1255 |
|---|---|
| container_issue | 11 |
| container_start_page | 1249 |
| container_title | Clinical transplantation |
| container_volume | 28 |
| creator | Florescu, Diana F. Kalil, Andre C. Qiu, Fang Grant, Wendy Morris, Michael C. Schmidt, Cynthia M. Florescu, Marius C. Poole, Jill A. |
| description | Background
Severe hypogammaglobulinemia (IgG |
| doi_str_mv | 10.1111/ctr.12458 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1654688348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1622064413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3968-2d59f6b5dc1410ca6ca26ea822a576881123640edbaec6232f36aa01bf19a93c3</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi0EotPCghdAXsIirX8ST7JCaGAGpAoQKurSunFupgY7Tu1kyrx9DdPpDglvrnV1viPLHyGvODvn-VyYKZ5zUVb1E7LgsmkKxrh4ShasYSLflTwhpyn9zFvFVfWcnIhKMFmxZkF2HwImagcTEZIdttR6Pw9h60I7OztQhzt0GfAjmImmOe7sDlwO0BSc7WiIWxjoFGFIo4NhohGNHS0OU6J3drqhN_sxbMF7OCrRW3j3gjzrwSV8-TDPyI_1x6vVp-Ly6-bz6v1lYWSj6kJ0VdOrtuoMLzkzoAwIhVALAdVS1TXnQqqSYdcCGiWk6KUCYLzteQONNPKMvDl4xxhuZ0yT9jYZdPmpGOak83eU2SPL-j9QIZgqSy4z-vaAmhhSitjrMVoPca85038a0bkR_beRzL5-0M6tx-6RPFaQgYsDcGcd7v9t0qur70dlcUjYNOHvxwTEX1ot5bLS1182-tvqeq3KzVozeQ8FUabC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1622064413</pqid></control><display><type>article</type><title>Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia?</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Florescu, Diana F. ; Kalil, Andre C. ; Qiu, Fang ; Grant, Wendy ; Morris, Michael C. ; Schmidt, Cynthia M. ; Florescu, Marius C. ; Poole, Jill A.</creator><creatorcontrib>Florescu, Diana F. ; Kalil, Andre C. ; Qiu, Fang ; Grant, Wendy ; Morris, Michael C. ; Schmidt, Cynthia M. ; Florescu, Marius C. ; Poole, Jill A.</creatorcontrib><description>Background
Severe hypogammaglobulinemia (IgG < 400 mg/dL) has adverse impact on mortality during the first year post‐transplantation. The aim of the study was to determine whether increasing IgG levels to ≥400 mg/dL improved outcomes.
Methods
Kaplan–Meier analyses were performed to estimate survival, log‐rank test to compare survival distributions between groups, and Fisher's exact test to determine the association between hypogammaglobulinemia and rejection or graft loss.
Results
Thirty‐seven solid organ transplant (SOT) recipients were included. Hypogammaglobulinemia was diagnosed at median of 5.6 months (range: 0–291.8 months) post‐transplantation. Types of transplants: liver–small bowel (17); liver–small bowel–kidney (2); liver (5); small bowel (4); liver–kidney (1); kidney/kidney–pancreas (3); heart (3); heart–kidney (1); and heart–lung (1). The three‐yr survival after the diagnosis of hypogammaglobulinemia was 49.5% (95% CI: 32.2–64.6%). Patients were dichotomized based upon IgG level at last follow‐up: IgG ≥ 400 mg/dL (23 patients) and IgG < 400 mg/dL (14 patients). There was no evidence of a difference in survival (p = 0.44), rejection rate (p = 0.44), and graft loss censored for death (p = 0.99) at one yr between these two groups. There was no difference in survival between patients receiving or not immunoglobulin (p = 0.99) or cytomegalovirus hyperimmunoglobulin (p = 0.14).
Conclusion
Severe hypogammaglobulinemia after SOT is associated with high mortality rates, but increasing IgG levels to ≥400 mg/dL did not seem to translate in better patient or graft survival in this cohort.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.12458</identifier><identifier>PMID: 25203509</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Agammaglobulinemia - complications ; Agammaglobulinemia - mortality ; Agammaglobulinemia - therapy ; Child ; Child, Preschool ; Cytomegalovirus ; Female ; Graft Rejection - blood ; Graft Survival ; Humans ; hypogammaglobulinemia ; immunoglobulin ; Immunoglobulin G - blood ; Immunologic Factors - therapeutic use ; Kaplan-Meier Estimate ; Male ; mortality ; Organ Transplantation - mortality ; Retrospective Studies ; survival ; transplantation ; Treatment Outcome</subject><ispartof>Clinical transplantation, 2014-11, Vol.28 (11), p.1249-1255</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3968-2d59f6b5dc1410ca6ca26ea822a576881123640edbaec6232f36aa01bf19a93c3</citedby><cites>FETCH-LOGICAL-c3968-2d59f6b5dc1410ca6ca26ea822a576881123640edbaec6232f36aa01bf19a93c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.12458$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.12458$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25203509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Florescu, Diana F.</creatorcontrib><creatorcontrib>Kalil, Andre C.</creatorcontrib><creatorcontrib>Qiu, Fang</creatorcontrib><creatorcontrib>Grant, Wendy</creatorcontrib><creatorcontrib>Morris, Michael C.</creatorcontrib><creatorcontrib>Schmidt, Cynthia M.</creatorcontrib><creatorcontrib>Florescu, Marius C.</creatorcontrib><creatorcontrib>Poole, Jill A.</creatorcontrib><title>Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia?</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Background
Severe hypogammaglobulinemia (IgG < 400 mg/dL) has adverse impact on mortality during the first year post‐transplantation. The aim of the study was to determine whether increasing IgG levels to ≥400 mg/dL improved outcomes.
Methods
Kaplan–Meier analyses were performed to estimate survival, log‐rank test to compare survival distributions between groups, and Fisher's exact test to determine the association between hypogammaglobulinemia and rejection or graft loss.
Results
Thirty‐seven solid organ transplant (SOT) recipients were included. Hypogammaglobulinemia was diagnosed at median of 5.6 months (range: 0–291.8 months) post‐transplantation. Types of transplants: liver–small bowel (17); liver–small bowel–kidney (2); liver (5); small bowel (4); liver–kidney (1); kidney/kidney–pancreas (3); heart (3); heart–kidney (1); and heart–lung (1). The three‐yr survival after the diagnosis of hypogammaglobulinemia was 49.5% (95% CI: 32.2–64.6%). Patients were dichotomized based upon IgG level at last follow‐up: IgG ≥ 400 mg/dL (23 patients) and IgG < 400 mg/dL (14 patients). There was no evidence of a difference in survival (p = 0.44), rejection rate (p = 0.44), and graft loss censored for death (p = 0.99) at one yr between these two groups. There was no difference in survival between patients receiving or not immunoglobulin (p = 0.99) or cytomegalovirus hyperimmunoglobulin (p = 0.14).
Conclusion
Severe hypogammaglobulinemia after SOT is associated with high mortality rates, but increasing IgG levels to ≥400 mg/dL did not seem to translate in better patient or graft survival in this cohort.</description><subject>Agammaglobulinemia - complications</subject><subject>Agammaglobulinemia - mortality</subject><subject>Agammaglobulinemia - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytomegalovirus</subject><subject>Female</subject><subject>Graft Rejection - blood</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>hypogammaglobulinemia</subject><subject>immunoglobulin</subject><subject>Immunoglobulin G - blood</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>mortality</subject><subject>Organ Transplantation - mortality</subject><subject>Retrospective Studies</subject><subject>survival</subject><subject>transplantation</subject><subject>Treatment Outcome</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EotPCghdAXsIirX8ST7JCaGAGpAoQKurSunFupgY7Tu1kyrx9DdPpDglvrnV1viPLHyGvODvn-VyYKZ5zUVb1E7LgsmkKxrh4ShasYSLflTwhpyn9zFvFVfWcnIhKMFmxZkF2HwImagcTEZIdttR6Pw9h60I7OztQhzt0GfAjmImmOe7sDlwO0BSc7WiIWxjoFGFIo4NhohGNHS0OU6J3drqhN_sxbMF7OCrRW3j3gjzrwSV8-TDPyI_1x6vVp-Ly6-bz6v1lYWSj6kJ0VdOrtuoMLzkzoAwIhVALAdVS1TXnQqqSYdcCGiWk6KUCYLzteQONNPKMvDl4xxhuZ0yT9jYZdPmpGOak83eU2SPL-j9QIZgqSy4z-vaAmhhSitjrMVoPca85038a0bkR_beRzL5-0M6tx-6RPFaQgYsDcGcd7v9t0qur70dlcUjYNOHvxwTEX1ot5bLS1182-tvqeq3KzVozeQ8FUabC</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Florescu, Diana F.</creator><creator>Kalil, Andre C.</creator><creator>Qiu, Fang</creator><creator>Grant, Wendy</creator><creator>Morris, Michael C.</creator><creator>Schmidt, Cynthia M.</creator><creator>Florescu, Marius C.</creator><creator>Poole, Jill A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201411</creationdate><title>Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia?</title><author>Florescu, Diana F. ; Kalil, Andre C. ; Qiu, Fang ; Grant, Wendy ; Morris, Michael C. ; Schmidt, Cynthia M. ; Florescu, Marius C. ; Poole, Jill A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3968-2d59f6b5dc1410ca6ca26ea822a576881123640edbaec6232f36aa01bf19a93c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Agammaglobulinemia - complications</topic><topic>Agammaglobulinemia - mortality</topic><topic>Agammaglobulinemia - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytomegalovirus</topic><topic>Female</topic><topic>Graft Rejection - blood</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>hypogammaglobulinemia</topic><topic>immunoglobulin</topic><topic>Immunoglobulin G - blood</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>mortality</topic><topic>Organ Transplantation - mortality</topic><topic>Retrospective Studies</topic><topic>survival</topic><topic>transplantation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Florescu, Diana F.</creatorcontrib><creatorcontrib>Kalil, Andre C.</creatorcontrib><creatorcontrib>Qiu, Fang</creatorcontrib><creatorcontrib>Grant, Wendy</creatorcontrib><creatorcontrib>Morris, Michael C.</creatorcontrib><creatorcontrib>Schmidt, Cynthia M.</creatorcontrib><creatorcontrib>Florescu, Marius C.</creatorcontrib><creatorcontrib>Poole, Jill A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Florescu, Diana F.</au><au>Kalil, Andre C.</au><au>Qiu, Fang</au><au>Grant, Wendy</au><au>Morris, Michael C.</au><au>Schmidt, Cynthia M.</au><au>Florescu, Marius C.</au><au>Poole, Jill A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia?</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2014-11</date><risdate>2014</risdate><volume>28</volume><issue>11</issue><spage>1249</spage><epage>1255</epage><pages>1249-1255</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>Background
Severe hypogammaglobulinemia (IgG < 400 mg/dL) has adverse impact on mortality during the first year post‐transplantation. The aim of the study was to determine whether increasing IgG levels to ≥400 mg/dL improved outcomes.
Methods
Kaplan–Meier analyses were performed to estimate survival, log‐rank test to compare survival distributions between groups, and Fisher's exact test to determine the association between hypogammaglobulinemia and rejection or graft loss.
Results
Thirty‐seven solid organ transplant (SOT) recipients were included. Hypogammaglobulinemia was diagnosed at median of 5.6 months (range: 0–291.8 months) post‐transplantation. Types of transplants: liver–small bowel (17); liver–small bowel–kidney (2); liver (5); small bowel (4); liver–kidney (1); kidney/kidney–pancreas (3); heart (3); heart–kidney (1); and heart–lung (1). The three‐yr survival after the diagnosis of hypogammaglobulinemia was 49.5% (95% CI: 32.2–64.6%). Patients were dichotomized based upon IgG level at last follow‐up: IgG ≥ 400 mg/dL (23 patients) and IgG < 400 mg/dL (14 patients). There was no evidence of a difference in survival (p = 0.44), rejection rate (p = 0.44), and graft loss censored for death (p = 0.99) at one yr between these two groups. There was no difference in survival between patients receiving or not immunoglobulin (p = 0.99) or cytomegalovirus hyperimmunoglobulin (p = 0.14).
Conclusion
Severe hypogammaglobulinemia after SOT is associated with high mortality rates, but increasing IgG levels to ≥400 mg/dL did not seem to translate in better patient or graft survival in this cohort.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>25203509</pmid><doi>10.1111/ctr.12458</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0902-0063 |
| ispartof | Clinical transplantation, 2014-11, Vol.28 (11), p.1249-1255 |
| issn | 0902-0063 1399-0012 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1654688348 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Agammaglobulinemia - complications Agammaglobulinemia - mortality Agammaglobulinemia - therapy Child Child, Preschool Cytomegalovirus Female Graft Rejection - blood Graft Survival Humans hypogammaglobulinemia immunoglobulin Immunoglobulin G - blood Immunologic Factors - therapeutic use Kaplan-Meier Estimate Male mortality Organ Transplantation - mortality Retrospective Studies survival transplantation Treatment Outcome |
| title | Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T06%3A07%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20increasing%20immunoglobulin%20levels%20impact%20survival%20in%20solid%20organ%20transplant%20recipients%20with%20hypogammaglobulinemia?&rft.jtitle=Clinical%20transplantation&rft.au=Florescu,%20Diana%20F.&rft.date=2014-11&rft.volume=28&rft.issue=11&rft.spage=1249&rft.epage=1255&rft.pages=1249-1255&rft.issn=0902-0063&rft.eissn=1399-0012&rft_id=info:doi/10.1111/ctr.12458&rft_dat=%3Cproquest_cross%3E1622064413%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1622064413&rft_id=info:pmid/25203509&rfr_iscdi=true |