Activation of 5-HT receptors inhibits GABAergic transmission by pre-and post-synaptic mechanisms in layer II/III of the juvenile rat auditory cortex

ABSTRACT The specific mechanisms by which serotonin (5‐HT) modulates synaptic transmission in the auditory cortex are still unknown. In this work, we used whole‐cell recordings from layer II/III of pyramidal neurons in rat brain slices to characterize the influence of 5‐HT on inhibitory synaptic act...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2015-03, Vol.69 (3), p.115-127
Hauptverfasser:	García-Oscos, Francisco, Torres-Ramírez, Oswaldo, Dinh, Lu, Galindo-Charles, Luis, Pérez Padilla, Elsy Arlene, Pineda, Juan Carlos, Atzori, Marco, Salgado, Humberto
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptors 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Amphetamines - pharmacology Animals auditory cortex Auditory Cortex - growth & development Auditory Cortex - metabolism Auditory Cortex - physiology cortical circuitry GABA Agonists - pharmacology GABA release GABAA receptors GABAergic Neurons - drug effects GABAergic Neurons - metabolism GABAergic Neurons - physiology Inhibitory Postsynaptic Potentials Miniature Postsynaptic Potentials Muscimol - pharmacology Piperazines - pharmacology Rats Rats, Sprague-Dawley Receptors, Serotonin - metabolism Ritanserin - pharmacology Serotonin Receptor Agonists - pharmacology Synapses - drug effects Synapses - metabolism Synapses - physiology whole-cell
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