Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

Monoamine oxidases (MAO) and cholinesterases are validated targets in the design of drugs for the treatment of Alzheimer's disease. The multi-target compound N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (ASS234), bearing the MAO-inhibiting p...

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Veröffentlicht in:	Biochimica et biophysica acta 2014-06, Vol.1844 (6), p.1104-1110
Hauptverfasser:	Esteban, Gerard, Allan, Jennifer, Samadi, Abdelouahid, Mattevi, Andrea, Unzeta, Mercedes, Marco-Contelles, José, Binda, Claudia, Ramsay, Rona R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Alzheimer’s disease ASS234 Butyrylcholinesterase - chemistry Clorgyline - chemistry Crystal structure Flavin adduct Flavin-Adenine Dinucleotide - chemistry Humans Indans - chemistry Indoles - chemistry Kinetics Models, Molecular Monoamine Oxidase - chemistry Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemistry Multi-target drug Neuroprotective Agents - chemistry PF9601N Piperidines - chemistry Recombinant Proteins - chemistry Recombinant Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
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