The influence of XRCC1 genetic variants on lung cancer susceptibility in Chinese Han population

Growing evidence suggests that genetic variants of X-ray repair cross-complementing group 1 proteins (XRCC1) contribute to genetic effects on the development of lung cancer. This case–control study aims to evaluate the genetic effects of XRCC1 c.482C>T and c.1686C>G single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. 391 lung cancer patients and 398 cancer-free controls were enrolled in this study. The genotypes of c.482C>T and c.1686C>G genetic variants were detected by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. The genetic effects on lung cancer susceptibility were evaluated using association analyses by the unconditional logistic regression model. Our data indicated that there were significant differences in the distribution of allelic and genotypic frequencies between lung cancer patients and cancer-free controls. The XRCC1 c.482C>T and c.1686C>G genetic variants were significantly associated with the susceptibility to lung cancer (for c.482C>T, TT versus (vs.) CC: OR=2.14, 95% CI 1.31–3.48, P=0.002; T vs. C: OR=1.37, 95% CI 1.10–1.69, P=0.004; for c.1686C>G, GG vs. CC: OR=2.53, 95% CI 1.46–4.38, P=0.001; G vs. C: OR=1.33, 95% CI 1.06–1.65, P=0.012). These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population. •The XRCC1 gene plays an important role in the pathogenesis of lung cancer.•The c.482C>T and c.1686C>G are associated with the risk of lung cancer.•The XRCC1 gene contributes to lung cancer in Chinese Han populations.