Pharmacogenomic study of the role of the nociceptin/orphanin FQ receptor and opioid receptors in diabetic hyperalgesia

Targeting functionally independent receptors may provide synergistic analgesic effects in neuropathic pain. To examine the interdependency between different opioid receptors (µ-opioid peptide [MOP], δ-opioid peptide [DOP] and κ-opioid peptide [KOP]) and the nociceptin/orphanin FQ peptide (NOP) recep...

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Veröffentlicht in:	European journal of pharmacology 2014-10, Vol.741, p.264-271
Hauptverfasser:	Rutten, Kris, Tzschentke, Thomas M., Koch, Thomas, Schiene, Klaus, Christoph, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Animals Antihyperalgesia Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Hyperalgesia - drug therapy Hyperalgesia - genetics Hyperalgesia - metabolism Knockout mice Male Mice Mice, Inbred C57BL Mice, Knockout Neuropathic pain Nociceptin/orphanin FQ receptor Opioid receptors ORL1 Rats Rats, Sprague-Dawley Receptors, Opioid - physiology Receptors, Opioid, mu - agonists Receptors, Opioid, mu - physiology
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