Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

TSPO is a neuroinflammatory biomarker and emerging therapeutic target in psychiatric disorders. We evaluated whether TSPO polymorphisms contribute to interindividual variability in schizophrenia, antipsychotic efficacy and antipsychotic-induced weight gain. We analyzed TSPO polymorphisms in 670 schi...

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Veröffentlicht in:	Pharmacogenomics 2015-01, Vol.16 (1), p.5-22
Hauptverfasser:	Pouget, Jennie G, Gonçalves, Vanessa F, Nurmi, Erika L, P Laughlin, Christopher, Mallya, Karyn S, McCracken, James T, Aman, Michael G, McDougle, Christopher J, Scahill, Lawrence, Misener, Virginia L, Tiwari, Arun K, Zai, Clement C, Brandl, Eva J, Felsky, Daniel, Leung, Amy Q, Lieberman, Jeffrey A, Meltzer, Herbert Y, Potkin, Steven G, Niedling, Charlotte, Steimer, Werner, Leucht, Stefan, Knight, Jo, Müller, Daniel J, Kennedy, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Drug therapy Female Genetic aspects Genetic Association Studies Genetic polymorphisms Health aspects Humans Male Mental disorders Middle Aged Receptors, GABA - genetics Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - pathology Transport proteins Treatment Outcome Weight Gain - genetics
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