Attenuation of ecstasy-induced neurotoxicity by N-acetylcysteine

Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) can lead to spatial memory impairments and hippocampal cell death. Numerous evidence indicates that the antioxidant N-acetylcysteine (NAC) exerts protective effects in the brain. The present study evaluates the effects of NAC on MDMA–induced neur...

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Veröffentlicht in:	Metabolic brain disease 2015-02, Vol.30 (1), p.171-181
Hauptverfasser:	Soleimani Asl, Sara, Saifi, Bita, Sakhaie, Abolhasan, Zargooshnia, Somayeh, Mehdizadeh, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - therapeutic use Animals Antioxidants - therapeutic use Apoptosis - drug effects bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Biochemistry Biomedical and Life Sciences Biomedicine CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology Drug Evaluation, Preclinical Learning Disorders - chemically induced Learning Disorders - prevention & control Male Maze Learning - drug effects Metabolic Diseases N-Methyl-3,4-methylenedioxyamphetamine - toxicity Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurology Neurosciences Oncology Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Rats Rats, Sprague-Dawley Research Article Spatial Memory - drug effects
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