Identification of a subnuclear body involved in sequence-specific cytokine RNA processing

Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding prote...

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Veröffentlicht in:	Nature communications 2015-01, Vol.6 (1), p.5791-5791, Article 5791
Hauptverfasser:	Lee, Sungwook, Lee, Taeyun A., Lee, Eunhye, Kang, Sujin, Park, Areum, Kim, Seung Won, Park, Hyo Jin, Yoon, Je-Hyun, Ha, Sang-Jun, Park, Taesun, Lee, Ju-Seog, Cheon, Jae Hee, Park, Boyoun
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/34 14/63 631/250/127/1213 631/337/458 631/80/642 82/1 82/29 82/80 96 96/106 96/109 96/35 Animals Biosynthesis Cytokines DNA-Binding Proteins - metabolism Electrophoretic Mobility Shift Assay Enzyme-Linked Immunosorbent Assay Humanities and Social Sciences Humans Immunity, Cellular - genetics Immunoblotting Immunoprecipitation In Situ Hybridization, Fluorescence Interleukin-10 - metabolism Interleukin-6 - metabolism Intranuclear Space - physiology Life sciences Lipopolysaccharides Lymphocytes Mice Mice, Inbred C57BL multidisciplinary Proteins Real-Time Polymerase Chain Reaction RNA Interference RNA Processing, Post-Transcriptional - physiology Science Science (multidisciplinary) Spliceosomes - metabolism Ubiquitination
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