HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis

Human papilloma virus is associated with cervical and other tumors, and several cellular conditions also play an important role in carcinogenesis. Human papilloma virus (HPV)-infected cells exhibit activation of NF-κB and STAT3 (mediators of inflammation), but little is known about their regulation...

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Veröffentlicht in:	Molecular and cellular biochemistry 2014-09, Vol.394 (1-2), p.77-90
Hauptverfasser:	Prabhavathy, Devan, Prabhakar, Bandaru Niranjana, Karunagaran, Devarajan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biochemistry Biomedical and Life Sciences Cardiology Cell Survival - drug effects DNA polymerases DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - virology HEK293 Cells HeLa Cells Human papillomavirus 16 Human papillomavirus 16 - genetics Human papillomavirus 16 - immunology Human papillomavirus 16 - metabolism Human papillomavirus 16 - pathogenicity Humans Inflammation Life Sciences MCF-7 Cells Medical Biochemistry Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - metabolism Oncology Papillomavirus infections Papillomavirus Infections - genetics Papillomavirus Infections - immunology Papillomavirus Infections - metabolism Papillomavirus Infections - pathology RNA Interference Signal Transduction - drug effects STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transfection Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology
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