The ceramide system as a novel antidepressant target

Highlights • Depression is a systems disorder including mood, behavioral, and peripheral somatic disturbances. • Ceramide is a crucial constituent of biological membranes and signaling lipid in all cells. • Brain ceramide controls hippocampal neurogenesis and depression-like behavior in animal model...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-06, Vol.35 (6), p.293-304
Hauptverfasser:	Kornhuber, Johannes, Müller, Christian P, Becker, Katrin Anne, Reichel, Martin, Gulbins, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	acid sphingomyelinase Advanced Basic Science Animals Antidepressive Agents - pharmacokinetics Antidepressive Agents - pharmacology Brain - drug effects Brain - metabolism ceramide Ceramides - metabolism depression Humans inflammation Molecular Targeted Therapy neurogenesis stress
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Beschreibung
Zusammenfassung:	Highlights • Depression is a systems disorder including mood, behavioral, and peripheral somatic disturbances. • Ceramide is a crucial constituent of biological membranes and signaling lipid in all cells. • Brain ceramide controls hippocampal neurogenesis and depression-like behavior in animal models. • The acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs. • Ceramide links brain dysfunction and somatic disturbances in major depressive disorder.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.04.003